Evidence map›Paper›PMID 32439019›Full record

ReviewThe Psychiatric clinics of North America2020

Translational Neuroscience in Autism: From Neuropathology to Transcranial Magnetic Stimulation Therapies.

Manuel F Casanova, Estate M Sokhadze, Emily L Casanova, Ioan Opris, Caio Abujadi, Marco Antonio Marcolin, Xiaoli Li

3 registry-linked trialsOpen access · greenAbstract readReview
In one paragraph

Review in The Psychiatric clinics of North America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06069323 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Therapeutic Use of Repetitive Transcranial Magnetic Stimulation (rTMS) in Pediatric Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Cohorts (ADHD): a Randomized, Sham-controlled Study.

TypeinterventionalSponsorOspedali Riuniti di FoggiaRan2023 to 2026Enrolled80ConditionsAutism Spectrum Disorder, ADHD, Neurodevelopmental DisordersArmsrepetitive Transcranial Magnetic Stimulation
NCT06524310 nacompletednot on this mapstarted 2024, after this paper: background citation

Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on Cognitive Functions and Behavior in Individuals With Autism Spectrum Disorder ( ASD)

TypeinterventionalSponsorKing Saud UniversityRan2024 to 2025Enrolled35ConditionsAutism Spectrum DisorderArmsStimulation with low frequency rTMS at 1 Hz
NCT07182331 naenrolling by invitationnot on this mapstarted 2025, after this paper: background citation

Effects of cTBS on Sensory Integration in Children With Autism Spectrum Disorder: A Randomized, Sham-Controlled Study Integrating Genetic Markers, MRI, fNIRS, and Temporal Binding Tasks

TypeinterventionalSponsorNeurolab PlusRan2025 to 2026Enrolled40ConditionsAutism Spectrum Disorder (ASD)ArmsContinuous Theta Burst Stimulation to Bilateral DLPFC, Sham Continuous Theta Burst Stimulation
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
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  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Manuel F CasanovaDepartment of Pediatrics, Division of Developmental Behavioral Pediatrics, Greenville Health System, 200 Patewood Drive, Suite A200, Greenville, SC 29615, USA. Electronic address: Manuel.Casanova@prismahealth.org.
Estate M SokhadzeUniversity of South Carolina School of Medicine Greenville, 200 Patewood Drive, Greenville, SC 29615, USA.
Emily L CasanovaUniversity of South Carolina School of Medicine Greenville, 200 Patewood Drive, Greenville, SC 29615, USA. Electronic address: https://twitter.com/EmLyWill.
Ioan OprisUniversity of Miami, Miller School of Medicine, Department Miami Project to Cure Paralysis, Miami, FL 33136, USA.
Caio AbujadiDepartment of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Marco Antonio MarcolinDepartment of Neurology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Xiaoli LiState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.
Universidade de São Paulo · BRUniversity of South Carolina · USBeijing Normal University · CNPrisma Health · USUniversity of Miami · US

Funding

Building a Selective Inhibitory Control Tone in Autism: An rTMS StudyR01MH086784 · NIMH · UNIVERSITY OF LOUISVILLE · PI CASANOVA, MANUEL F · 2009 to 2012
$884k
NIMH NIH HHS R01 MH086784
6 · The paper itself

Abstract

The presence of heterotopias, increased regional density of neurons at the gray-white matter junction, and focal cortical dysplasias all suggest an abnormality of neuronal migration in autism spectrum disorder (ASD). The abnormality is borne from a dissonance in timing between radial and tangentially migrating neuroblasts to the developing cortical plate. The uncoupling of excitatory and inhibitory cortical cells disturbs the coordinated interactions of neurons within local networks, thus providing abnormal patterns of brainwave activity in the gamma bandwidth. In ASD, gamma oscillation abnormalities and autonomic markers offer measures of therapeutic progress and help in the identification of subgroups.

Indexed as

Transcranial Magnetic StimulationAutism Spectrum DisorderBrainChildExecutive FunctionHumansAutism spectrum disorderExecutive functionGamma oscillationsMinicolumnsTranscranial magnetic stimulation

Identifiers

PMID32439019
PMCPMC7245584
OpenAlexW3015795734

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.