Evidence map›Paper›PMID 32438944›Full record

ArticlePsychological medicine2021

Elucidating negative symptoms in the daily life of individuals in the early stages of psychosis.

Karlijn S F M Hermans, Inez Myin-Germeys, Charlotte Gayer-Anderson, Matthew J Kempton, Lucia Valmaggia, Philip McGuire, Robin M Murray, Philippa Garety, Til Wykes, Craig Morgan and 2 more

Open access · hybridAbstract readComparative Study
In one paragraph

Article in Psychological medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 3 countries.

Karlijn S F M HermansDepartment of Neuroscience, Center for Contextual Psychiatry, Catholic University of Leuven, Leuven, Belgium.ORCID 0000-0003-3570-6479
Inez Myin-GermeysDepartment of Neuroscience, Center for Contextual Psychiatry, Catholic University of Leuven, Leuven, Belgium.
Charlotte Gayer-AndersonHealth Service and Population Research Department, Centre for Epidemiology and Public Health, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Matthew J KemptonDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Lucia ValmaggiaPsychology Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Philip McGuireDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Robin M MurrayDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Philippa GaretyPsychology Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Til WykesPsychology Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Craig MorganHealth Service and Population Research Department, Centre for Epidemiology and Public Health, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Zuzana KasanovaDepartment of Neuroscience, Center for Contextual Psychiatry, Catholic University of Leuven, Leuven, Belgium.
Ulrich ReininghausHealth Service and Population Research Department, Centre for Epidemiology and Public Health, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
King's College London · GBKU Leuven · BE

Funding

Department of HealthMedical Research Council MR/J008915/1Wellcome TrustWellcome Trust WT087417
6 · The paper itself

Abstract

backgroundIt remains poorly understood how negative symptoms are experienced in the daily lives of individuals in the early stages of psychosis. We aimed to investigate whether altered affective experience, anhedonia, social anhedonia, and asociality were more pronounced in individuals with an at-risk mental state for psychosis (ARMS) and individuals with first-episode psychosis (FEP) than in controls.

methodsWe used the experience sampling methodology (ESM) to assess negative symptoms, as they occurred in the daily life of 51 individuals with FEP and 46 ARMS, compared with 53 controls.

resultsMultilevel linear regression analyses showed no overall evidence for a blunting of affective experience. There was some evidence for anhedonia in FEP but not in ARMS, as shown by a smaller increase of positive affect (BΔat-risk v. FEP = 0.08, p = 0.006) as the pleasantness of activities increased. Against our expectations, no evidence was found for greater social anhedonia in any group. FEP were more often alone (57%) than ARMS (38%) and controls (35%) but appraisals of the social situation did not point to asociality.

conclusionsOverall, altered affective experience, anhedonia, social anhedonia and asociality seem to play less of a role in the daily life of individuals in the early stages of psychosis than previously assumed. With the experience of affect and pleasure in daily life being largely intact, changing social situations and appraisals thereof should be further investigated to prevent development or deterioration of negative symptoms.

Indexed as

AnhedoniaAdolescentAdultAffective SymptomsAntisocial Personality DisorderFemaleHumansLondonMaleMiddle AgedPleasurePsychotic DisordersSocial BehaviorYoung Adultaltered affective experienceasocialityexperience sampling method(social) anhedonia

Identifiers

PMID32438944
PMCPMC8579154
OpenAlexW3026461101

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.