Evidence map›Paper›PMID 32438931›Full record

ArticleEpidemiology and infection2020

Mantao Chen, Chongchao Chen, Qing Yang, Renya Zhan

Abstract read
In one paragraph

Article in Epidemiology and infection, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Management of pedıatrıc Candıda central nervous system ınfectıons: a retrospectıve analysıs of a challengıng case serıes.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026
    Article
  2. Article
  3. Diagnostics (Basel, Switzerland) · 2026
    Article
  4. Article
  5. A case of central nervous system infection byMedical mycology case reports · 2022
    Article
  6. ChronicClinical case reports · 2022
    Article
  7. Review
  8. Article
  9. Article
  10. Single and Repeated Episodes ofFrontiers in microbiology · 2021
    Article
  11. Review
  12. Flucytosine and its clinical usage.Therapeutic advances in infectious disease
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mantao ChenDivision of Neurosurgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou310003, China.ORCID 0000-0001-7666-0759
Chongchao ChenDivision of Clinical Laboratory, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou310003, China.
Qing YangDivision of Clinical Laboratory, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou310003, China.
Renya ZhanDivision of Neurosurgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou310003, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Candida meningitis in neurosurgical patients is relatively unusual but is associated with a high mortality rate. We present our experience with this infection and discuss the clinical characteristics, treatment options and outcomes. We retrospectively reviewed neurosurgical patients with multiple positive cerebrospinal fluid (CSF) culture results in our hospital from January 2013 to December 2019. Nine patients were available for review according to our inclusion and exclusion criteria. Four species of Candida were isolated from the CSF samples and Candida albicans accounted for half of all infections. Eight infections were associated with ventricle peritoneal shunt, lumbar cistern peritoneal shunt or external ventricular drain. All of these foreign intracranial materials were removed or changed and all the patients received antifungal treatment, including fluconazole and/or voriconazole. It is associated with severe long-term outcomes in survivors and a mortality rate that reaches 11.1%. Prior treatments with broad-spectrum and high-grade antibiotics and anaemia are possible risk factors for Candida meningitis. We advise that foreign intracranial material should be removed or changed as early as possible and the timing of re-shunt operation can be 1 month after control of Candida meningitis has been achieved, with several negative CSF culture results.

Indexed as

AdultAgedAntifungal AgentsCandidiasisFemaleHumansMaleMeningitis, FungalMiddle AgedNeurosurgical ProceduresRetrospective StudiesRisk FactorsAntifungal AgentsCandidameningitisneurosurgeryrisk factortherapy

Identifiers

PMID32438931
PMCPMC7374802

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.