ArticleMicrobiome2020
The microbiome as a biosensor: functional profiles elucidate hidden stress in hosts.
Article in Microbiome, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
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- Abiotic Treatment to Common Bean Plants Results in an Altered Endophytic Seed Microbiome.Microbiology spectrum · 2022Article
- Advancement of Metatranscriptomics towards Productive Agriculture and Sustainable Environment: A Review.International journal of molecular sciences · 2022Review
- Bioprospecting Microbiome for Soil and Plant Health Management Amidst Huanglongbing Threat in Citrus: A Review.Frontiers in plant science · 2022Review
- Microbe-assisted crop improvement: a sustainable weapon to restore holobiont functionality and resilience.Horticulture research · 2022Article
- Modified Nanodiamonds as a Means of Polymer Surface Functionalization. From Fouling Suppression to Biosensor Design.Nanomaterials (Basel, Switzerland) · 2021Article
- clusterProfiler 4.0: A universal enrichment tool for interpreting omics data.Innovation (Cambridge (Mass.)) · 2021Article
- Tapirus bairdii-Associated Fecal Microbiome from a Critical Conservation Area: Calakmul, México.Current microbiology · 2021Article
- Unveiling the putative functional genes present in root-associated endophytic microbiome from maize plant using the shotgun approach.Journal of applied genetics · 2021Article
- Holo-omics for deciphering plant-microbiome interactions.Microbiome · 2021Review
- Correction to: The microbiome as a biosensor: functional profiles elucidate hidden stress in hosts.Microbiome · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundMicrobial communities are highly responsive to environmental cues, and both their structure and activity can be altered in response to changing conditions. We hypothesized that host-associated microbial communities, particularly those colonizing host surfaces, can serve as in situ sensors to reveal environmental conditions experienced by both microorganisms and the host. For a proof-of-concept, we studied a model plant-soil system and employed a non-deterministic gene-centric approach. A holistic analysis was performed using plants of two species and irrigation with water of low quality to induce host stress. Our analyses examined the genetic potential (DNA) and gene expression patterns (RNA) of plant-associated microbial communities, as well as transcriptional profiling of host plants.
resultsTranscriptional analysis of plants irrigated with treated wastewater revealed significant enrichment of general stress-associated root transcripts relative to plants irrigated with fresh water. Metagenomic analysis of root-associated microbial communities in treated wastewater-irrigated plants, however, revealed enrichment of more specific stress-associated genes relating to high levels of salt, high pH and lower levels of oxygen. Meta-analysis of these differentially abundant genes obtained from other metagenome studies, provided evidence of the link between environmental factors such as pH and oxygen and these genes. Analysis of microbial transcriptional response demonstrated that enriched gene content was actively expressed, which implies contemporary response to elevated levels of pH and salt.
conclusionsWe demonstrate here that microbial profiling can elucidate stress signals that cannot be observed even through interrogation of host transcriptome, leading to an alternate mechanism for evaluating in situ conditions experienced by host organisms. This study is a proof-of-concept for the use of microbial communities as microsensors, with great potential for interrogation of a wide range of host systems. Video Abstract.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.