Evidence map›Paper›PMID 32438662›Full record

ArticleCells2020

Concerted EP2 and EP4 Receptor Signaling Stimulates Autocrine Prostaglandin E

Eva Mangelsen, Michael Rothe, Angela Schulz, Aikaterini Kourpa, Daniela Panáková, Reinhold Kreutz, Juliane Bolbrinker

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Eva MangelsenCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Clinical Pharmacology and Toxicology, Charitéplatz 1, 10117 Berlin, Germany.ORCID 0000-0003-2418-8805
Michael RotheLipidomix GmbH, Robert-Rössle-Str. 10, B55, 13125 Berlin, Germany.
Angela SchulzCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Clinical Pharmacology and Toxicology, Charitéplatz 1, 10117 Berlin, Germany.
Aikaterini KourpaMax Delbrück Center for Molecular Medicine in the Helmholtz Association, Electrochemical Signaling in Development and Disease, Robert-Rössle-Str. 10, 13125 Berlin, Germany.
Daniela PanákováMax Delbrück Center for Molecular Medicine in the Helmholtz Association, Electrochemical Signaling in Development and Disease, Robert-Rössle-Str. 10, 13125 Berlin, Germany.
Reinhold KreutzCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Clinical Pharmacology and Toxicology, Charitéplatz 1, 10117 Berlin, Germany.
Juliane BolbrinkerCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Clinical Pharmacology and Toxicology, Charitéplatz 1, 10117 Berlin, Germany.ORCID 0000-0002-0812-8549
Humboldt-Universität zu Berlin · DEMax Delbrück Center · DELipidomix (Germany) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glomerular hyperfiltration is an important mechanism in the development of albuminuria. During hyperfiltration, podocytes are exposed to increased fluid flow shear stress (FFSS) in Bowman's space. Elevated Prostaglandin E2 (PGE

Indexed as

Autocrine CommunicationSignal TransductionAnimalsCell DifferentiationCyclic AMPCyclooxygenase 2DinoprostoneDisease Models, AnimalGene Expression RegulationHumansMetabolomePodocytesRats, WistarReceptors, Prostaglandin E, EP2 SubtypeReceptors, Prostaglandin E, EP4 SubtypeRenal Insufficiency, Chronic15-ketoprostaglandin E2Cyclic AMPCyclooxygenase 2DinoprostoneReceptors, Prostaglandin E, EP2 SubtypeReceptors, Prostaglandin E, EP4 Subtypechronic kidney diseaseCOX2EP2EP4G protein-coupled receptor (GPCR) signalinghyperfiltrationLC/ESI-MS/MSMWFpodocyteprostaglandin E2SHR

Identifiers

PMID32438662
PMCPMC7290667
OpenAlexW3027353001

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.