Evidence map›Paper›PMID 32438591›Full record

ArticleGenes2020

Characterizing Y-STRs in the Evaluation of Population Differentiation Using the Mean of Allele Frequency Difference between Populations.

Yuxiang Zhou, Yining Yao, Baonian Liu, Qinrui Yang, Zhihan Zhou, Chengchen Shao, Shilin Li, Qiqun Tang, Jianhui Xie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuxiang ZhouDepartment of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
Yining YaoDepartment of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
Baonian LiuDepartment of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
Qinrui YangDepartment of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
Zhihan ZhouDepartment of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
Chengchen ShaoDepartment of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
Shilin LiMinistry of Education Key Laboratory of Contemporary Anthropology and State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200433, China.
Qiqun TangDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
Jianhui XieDepartment of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Y-chromosomal short tandem repeats (Y-STRs) are widely used in human research for the evaluation of population substructure or population differentiation. Previous studies show that several haplotype sets can be used for the evaluation of population differentiation. However, little is known about whether each Y-STR in these sets performs well during this procedure. In this study, a total of 20,927 haplotypes of a Yfiler Plus set were collected from 41 global populations. Different configurations were observed in multidimensional scaling (MDS) plots based on pairwise genetic distances evaluated using a Yfiler set and a Yfiler Plus set, respectively. Subsequently, 23 single-copy Y-STRs were characterized in the evaluation of population differentiation using the mean of allele frequency difference (mAFD) between populations. Our results indicated that DYS392 had the largest mAFD value (0.3802) and YGATAH4 had the smallest value (0.1845). On the whole, larger pairwise genetic distances could be obtained using the set with the top fifteen markers from these 23 single-copy Y-STRs, and clear clustering or separation of populations could be observed in the MDS plot in comparison with those using the set with the minimum fifteen markers. In conclusion, the mAFD value is reliable to characterize Y-STRs for efficiency in the evaluation of population differentiation.

Indexed as

Genetics, PopulationChromosomes, Human, YDNA FingerprintingEthnicityForensic GeneticsGene FrequencyGenetic VariationHaplotypesHumansMaleMicrosatellite Repeatsallele frequency differencemultidimensional scalingpairwise genetic distancepopulation differentiationY-STR

Identifiers

PMID32438591
PMCPMC7290957

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.