ArticlePolymers2020
Biomimetic Composite Scaffold Based on Naturally Derived Biomaterials.
Article in Polymers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- Cancer treatment-related cardiotoxicity, molecular mechanism, challenges, and research trends.Discover oncology · 2026Review
- Biomimetic polymers and their characterization: toward sustainable materials using synthetic biology.Frontiers in chemistry · 2026Review
- Advances in novel biomaterials for cardiovascular tissue engineering and regenerative medicine.PeerJ · 2026Review
- Biomimetic Strategies for Bone Regeneration: Smart Scaffolds and Multiscale Cues.Biomimetics (Basel, Switzerland) · 2025Review
- Biomaterials-based approaches to mandibular tissue engineering: where we were, where we are, where we are going.Regenerative biomaterials · 2025Review
- Piezoelectric Biocomposites for Bone Grafting in Dentistry.Polymers · 2023Article
- A Review of the Application of Natural and Synthetic Scaffolds in Bone Regeneration.Journal of functional biomaterials · 2023Review
- Eggshell Membrane as a Biomaterial for Bone Regeneration.Polymers · 2023Review
- Hydrothermally synthesized titanium/hydroxyapatite as photoactive and antibacterial biomaterial.Heliyon · 2023Article
- Biomimetic Remineralized Three-Dimensional Collagen Bone Matrices with an Enhanced Osteostimulating Effect.Biomimetics (Basel, Switzerland) · 2023Article
- The Effect of Germanium-Loaded Hydroxyapatite Biomaterials on Bone Marrow Mesenchymal Stem Cells Growth.Cells · 2022Article
- Dicalcium Phosphate Dihydrate Mineral Loaded Freeze-Dried Scaffolds for Potential Synthetic Bone Applications.Materials (Basel, Switzerland) · 2022Article
- Locally Applied Repositioned Hormones for Oral Bone and Periodontal Tissue Engineering: A Narrative Review.Polymers · 2022Review
- Biological Behavior of Xenogenic Scaffolds in Alcohol-Induced Rats: Histomorphometric and Picrosirius Red Staining Analysis.Polymers · 2022Article
- Synthesis and Characterization of Calcium Phosphate Materials Derived from Eggshells from Different Poultry with and without the Eggshell Membrane.Materials (Basel, Switzerland) · 2022Article
- Application of decellularized bone matrix as a bioscaffold in bone tissue engineering.Journal of biological engineering · 2022Review
- In Vitro Degradation and Cytotoxicity of Eggshell-Based Hydroxyapatite: A Systematic Review and Meta-Analysis.Polymers · 2021Review
- Additive Fabrication and Characterization of Biomimetic Composite Bone Scaffolds with High Hydroxyapatite Content.Gels (Basel, Switzerland) · 2021Article
- Collagen-Carboxymethylcellulose Biocomposite Wound-Dressings with Antimicrobial Activity.Materials (Basel, Switzerland) · 2021Article
- Biocompatibility Studies on a Collagen-Hydroxyapatite Biomaterial.Current health sciences journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper proposes the development of a biomimetic composite based on naturally derived biomaterials. This freeze-dried scaffold contains a microwave-synthesized form of biomimetic hydroxyapatite (HAp), using the interwoven hierarchical structure of eggshell membrane (ESM) as bio-template. The bone regeneration capacity of the scaffold is enhanced with the help of added tricalcium phosphate from bovine Bone ash (BA). With the addition of Gelatin (Gel) and Chitosan (CS) as organic matrix, the obtained composite is characterized by the ability to stimulate the cellular response and might accelerate the bone healing process. Structural characterization of the synthesized HAp (ESM) confirms the presence of both hydroxyapatite and monetite phases, in accordance with the spectroscopy results on the ESM before and after the microwave thermal treatment (the presence of phosphate group). Morphology studies on all individual components and final scaffold, highlight their morphology and porous structure, characteristics that influence the biocompatibility of the scaffold. Porosity, swelling rate and the in vitro cytotoxicity assays performed on amniotic fluid stem cells (AFSC), demonstrate the effective biocompatibility of the obtained materials. The experimental results presented in this paper highlight an original biocomposite scaffold obtained from naturally derived materials, in a nontoxic manner.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.