ArticleJournal of child psychology and psychiatry, and allied disciplines2021
Psychobiological markers of allostatic load in depressed and nondepressed mothers and their adolescent offspring.
Article in Journal of child psychology and psychiatry, and allied disciplines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Allostatic Load in Children and Adolescents: A Systematic Review.Psychotherapy and psychosomatics · 2023Pooled it
- A systematic review and meta-analysis of the association between parenting and child autonomic nervous system activity.Neuroscience and biobehavioral reviews · 2022Pooled it
- Stress-related multisystem dysregulation during adolescence predicts mental health symptoms in young adulthood.Psychological medicine · 2025Article
- Early Parenting Effects on Childhood Delay of Gratification and Adolescent Allostatic Load.Children (Basel, Switzerland) · 2025Article
- Temperament and sex as moderating factors of the effects of exposure to maternal depression on telomere length in early childhood.Development and psychopathology · 2025Article
- Associations of depressive symptoms and cortisol with cognitive performance among memory clinic patients.International psychogeriatrics · 2025Observational
- Warm Parenting Throughout Adolescence Predicts Basal Parasympathetic Activity Among Mexican-Origin Youths.Developmental psychobiology · 2025Article
- Comparison between grip strength and relative grip strength in their relationship with allostatic load among adolescents.BMC public health · 2024Article
- Maternal Depressive Symptoms in the First Year after Childbirth Predict Long-Term Developmental Risks in Sons and Daughters.International journal of environmental research and public health · 2024Article
- SMURF: Statistical Modality Uniqueness and Redundancy Factorization.Proceedings of the ... ACM International Conference on Multimodal Interaction. ICMI (Conference) · 2024Article
- Allostatic load in children: The cost of empathic concern.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Interpersonal Life Stress and Inflammatory Reactivity as Prospective Predictors of Suicide Attempts in Adolescent Females.Research on child and adolescent psychopathology · 2023Article
- The interaction of socioeconomic stress and race on telomere length in children: A systematic review and meta-analysis.SSM - population health · 2023Article
- SHAP-based Prediction of Mother's History of Depression to Understand the Influence on Child Behavior.Proceedings of the ... ACM International Conference on Multimodal Interaction. ICMI (Conference) · 2023Article
- Multimodal Feature Selection for Detecting Mothers' Depression in Dyadic Interactions with their Adolescent Offspring.IEEE transactions on affective computing · 2023Article
- Beyond Additive Fusion: Learning Non-Additive Multimodal Interactions.Findings of ACL. EMNLP. Conference on Empirical Methods in Natural Language Processing · 2022Article
- The impact of depression on mothers' neural processing of their adolescents' affective behavior.Social cognitive and affective neuroscience · 2022Article
- Associations of youth mental health, parental psychological distress, and family relationships during the COVID-19 outbreak in China.BMC psychiatry · 2022Article
- The impact of social disadvantage on autonomic physiology of latinx adolescents: The role of environmental risks.New directions for child and adolescent development · 2022Article
- A multi-center study on the association between serum magnesium levels and allostatic load in hemodialysis patients.Frontiers in physiology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundA substantial body of research has emerged suggesting that depression is strongly linked to poor physical health outcomes, which may be partly due to increased allostatic load across stress response systems. Interestingly, health risks associated with depression are also borne by the offspring of depressed persons. Our aim was to simultaneously investigate whether maternal depression is associated not only with increased allostatic load across cardiac control, inflammation, cellular aging, but also if this is transmitted to adolescent children, possibly increasing the risk for early onset of psychiatric conditions and disease in these offspring.
methodsA preregistered, case-control study of 180 low-income mothers (50% mothers depressed, 50% mothers nondepressed) and their adolescent offspring was conducted to determine how depressed mothers and their adolescent offspring systematically differ in terms of autonomic, sympathetic, and parasympathetic cardiac control; inflammation; cellular aging; and behavioral health in offspring, which are indicators suggestive of higher allostatic load.
resultsFindings indicate that depressed mothers and their adolescent offspring differ in terms of comorbid mental and physical health risk profiles that are suggestive of higher allostatic load. Findings indicate that depressed mothers exhibit elevated resting heart rate and decreased heart rate variability, and adolescent offspring of depressed mothers exhibit greater mental health symptoms, elevated heart rate, and accelerated biological aging (shorter telomeres). These effects persisted after controlling for a range of potential covariates, including medication use, sex, age, and adolescents' own mental health symptoms.
conclusionsFindings indicate that maternal depression is associated with increased allostatic load in depressed women and their adolescent children, possibly increasing risk for early onset of psychiatric conditions and disease in these offspring. Future research is needed to delineate why some biological systems are more impacted than others and to explore how findings might inform preventative programs targeted at adolescent offspring of depressed mothers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.