Evidence map›Paper›PMID 32438474›Full record

ArticleAngewandte Chemie (International ed. in English)2020

Protein and mRNA Delivery Enabled by Cholesteryl-Based Biodegradable Lipidoid Nanoparticles.

Yamin Li, Rachel Jarvis, Kuixin Zhu, Zachary Glass, Roza Ogurlu, Peiyang Gao, Peixuan Li, Jinjin Chen, Yingjie Yu, Yongjie Yang and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Combinatorial design of ionizable lipid nanoparticles for muscle-selective mRNA delivery with minimized off-target effects.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  16. Article
  17. Review
  18. Nucleic acid drug vectors for diagnosis and treatment of brain diseases.Signal transduction and targeted therapy · 2023
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Yamin LiDepartment of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.
Rachel JarvisDepartment of Neuroscience, Tufts University, Boston, MA, 02111, USA.
Kuixin ZhuDepartment of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.
Zachary GlassDepartment of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.
Roza OgurluDepartment of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.
Peiyang GaoDepartment of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.
Peixuan LiDepartment of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.
Jinjin ChenDepartment of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.
Yingjie YuDepartment of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.
Yongjie YangDepartment of Neuroscience, Tufts University, Boston, MA, 02111, USA.
Qiaobing XuDepartment of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.ORCID 0000-0001-7323-7795
Tufts University · US

Funding

Efficient in Vivo RNP-based Gene Editing in the Sensory Organ Inner Ear Using Bioreducible Lipid NanoparticlesUG3TR002636 · NCATS · MASSACHUSETTS EYE AND EAR INFIRMARY · PI CHEN, ZHENG-YI, LIU, DAVID R · 2018 to 2020
$2.4M
ROS-responsive Chemical Modification of Protein and Its DeliveryR01EB027170 · NIBIB · TUFTS UNIVERSITY MEDFORD · PI XU, QIAOBING · 2018 to 2022
$1.4M
NCATS NIH HHS UG3 TR002636NIBIB NIH HHS R01 EB027170
6 · The paper itself

Abstract

Developing safe and efficient delivery systems for therapeutic biomacromolecules is a long-standing challenge. Herein, we report a newly developed combinatorial library of cholesteryl-based disulfide bond-containing biodegradable cationic lipidoid nanoparticles. We have identified a subset of this library which is effective for protein and mRNA delivery in vitro and in vivo. These lipidoids showed comparable transfection efficacies but much lower cytotoxicities compared to the Lpf2k in vitro. In vivo studies in adult mice demonstrated the successful delivery of genome engineering protein and mRNA molecules in the skeletal muscle (via intramuscular injection), lung and spleen (via intravenous injection), and brain (via lateral ventricle infusion).

Indexed as

AnimalsHumansMiceNanoparticlesProteinsRNA, MessengerProteinsRNA, Messengergenome engineeringlipidoid nanoparticlemRNA deliveryprotein deliverystimuli responsive

Identifiers

PMID32438474
PMCPMC7679290
OpenAlexW3026681247

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.