ArticleEuropean journal of dentistry2020
Effectiveness of Probiotic Lozenges in Periodontal Management of Chronic Periodontitis Patients: Clinical and Immunological Study.
Article in European journal of dentistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Probiotics in the non-surgical treatment of periodontitis: a systematic review and network meta-analysis.BMC oral health · 2024Pooled it
- Overview of oral health status and associated risk factors in maritime settings: An updated systematic review.PloS one · 2023Pooled it
- Pooled it
- Probiotics in Periodontal Diseases: Mechanisms, Evidence Mapping, Limitations, and Future Directions.Cureus · 2025Review
- Association between Dietary Live Microbe Intake and Periodontitis in Adults: Evidence from NHANES.Oral health & preventive dentistry · 2025Article
- Article
- Probiotics as an adjunctive therapy in periodontitis treatment-reality or illusion-a clinical perspective.NPJ biofilms and microbiomes · 2024Review
- Probiotics in the Prevention and Treatment of Periodontal Diseases: A Systematic Review.Journal of pharmacy & bioallied sciences · 2024Article
- Limosilactobacillus reuteri as an Adjuvant in the Treatment of Peri-implant Mucositis in Total Rehabilitation: An Exploratory Study.European journal of dentistry · 2024Article
- Accounting for the health risk of probiotics.Heliyon · 2024Review
- Periodontal disease in down syndrome: Predisposing factors and potential non-surgical therapeutic approaches.Journal of clinical laboratory analysis · 2024Review
- Clinical, microbiological and immunological short, medium and long-term effects of different strains of probiotics as an adjunct to non-surgical periodontal therapy in patients with periodontitis. Systematic review with meta-analysis.The Japanese dental science review · 2023Review
- The Emerging Role of MMP12 in the Oral Environment.International journal of molecular sciences · 2023Review
- The Effect of Periodontal Therapy on the Level of MMP-8 in Patients with Chronic Periodontitis.European journal of dentistry · 2023Article
- Personalized Treatment of Periodontitis in a Patient with McArdle's Disease: The Benefits from Probiotics.Case reports in dentistry · 2023Article
- ProbResist: a database for drug-resistant probiotic bacteria.Database : the journal of biological databases and curation · 2022Article
- Assessing the drug resistance profiles of oral probiotic lozenges.Journal of oral microbiology · 2022Article
- Probiotics ameliorate alveolar bone loss by regulating gut microbiota.Cell proliferation · 2021Article
- The differences in the number of fibroblasts and blood vessels after the topical and systemic administration ofVeterinary world · 2021Article
- Chemical plaque control - A brief review.Journal of family medicine and primary care · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe main purpose of this article was to evaluate the effect of probiotics used as an adjunctive to scaling and root planing (SRP) on the periodontal parameters and matrix metalloproteinase-8 (MMP-8) levels in gingival crevicular fluid (GCF) of chronic periodontitis patients. MATERIALS AND
methodsA total of 25 chronic periodontitis patients who completed the treatment course of 40 subjects, aged 25 to 58 years, participated in this study. They were categorized into two groups: the first group was treated by SRP while the second group was treated by SRP and probiotic lozenges twice a day for 30 days. All patients were evaluated clinically by measuring the plaque index, bleeding index (BI), pocket depth, clinical attachment loss, and immunologically by assaying GCF/MMP-8 at baseline and 30 days after periodontal management.
resultsThere was a significant improvement in periodontal parameters after SRP treatment with and without probiotic lozenges in both groups. However, there was a significant decrease in the BI (
conclusionThe current study suggested that the probiotics might have a beneficial effect on clinical and immunological outcomes in the management of chronic periodontitis patients. Further research is needed on a large-scale population and for a long recall time to confirm the response to probiotics as an adjunctive to SRP.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.