Evidence map›Paper›PMID 32438074›Full record

ReviewTranslational research : the journal of laboratory and clinical medicine2020

Therapeutic Vaccines for the Treatment of HIV.

Zhilin Chen, Boris Julg

Abstract readReview
In one paragraph

Review in Translational research : the journal of laboratory and clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Searching for a HIV-1 Cure.Theranostics · 2026
    Review
  6. Review
  7. HIV Virion Capturing Liposomes for Therapeutic Vaccination.bioRxiv : the preprint server for biology · 2025
    Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Modelling HIV-1 control and remission.NPJ systems biology and applications · 2024
    Review
  17. Advanced Therapies for Human Immunodeficiency Virus.Medical sciences (Basel, Switzerland) · 2024
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Zhilin ChenRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Boris JulgRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Infectious Disease Unit, Massachusetts General Hospital, Boston, MA, USA. Electronic address: BJULG@mgh.harvard.edu.

Funding

Ad26 Based Therapeutic Vaccines for HIVU01AI145801 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BAROUCH, DAN H., JUELG, BORIS DOMINIK · 2020 to 2025
$9.0M
Optimizing HIV-specific T-cell responses by therapeutic vaccinationR01AI138790 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI JUELG, BORIS DOMINIK · 2019 to 2024
$2.8M
NIAID NIH HHS R01 AI138790NIAID NIH HHS U01 AI145801
6 · The paper itself

Abstract

Despite the success of anti-retroviral therapy (ART) in transforming HIV into a manageable disease, it has become evident that long-term ART will not eliminate the HIV reservoir and cure the infection. Alternative strategies to eradicate HIV infection, or at least induce a state of viral control and drug-free remission are therefore needed. Therapeutic vaccination aims to induce or enhance immunity to alter the course of a disease. In this review we provide an overview of the current state of therapeutic HIV vaccine research and summarize the obstacles that the field faces while highlighting potential ways forward for a strategy to cure HIV infection.

Indexed as

AIDS VaccinesCytotoxicity, ImmunologicDisease ReservoirsHIV InfectionsHumansT-Lymphocytes, CytotoxicAIDS VaccinesAdaptive immune responsesHIVHIV cureTherapeutic vaccination

Identifiers

PMID32438074
PMCPMC8188575

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.