Evidence map›Paper›PMID 32438073›Full record

ReviewTranslational research : the journal of laboratory and clinical medicine2020

New and alternative strategies for the prevention, control, and treatment of antibiotic-resistant Campylobacter.

Lei Dai, Orhan Sahin, Madhusudan Grover, Qijing Zhang

Open access · greenAbstract readReview
In one paragraph

Review in Translational research : the journal of laboratory and clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 2 pooled it
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 2 syntheses or guidelines pooled it, 136 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. When Disinfection Fails: Biocide Tolerance as a Driver ofAntibiotics (Basel, Switzerland) · 2026
    Review
  6. Journal of veterinary research · 2026
    Article
  7. Detection and Characterization of ThermotolerantAntibiotics (Basel, Switzerland) · 2026
    Article
  8. Article
  9. Article
  10. InvestigatingVeterinary medicine international · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Serine Utilization byFood safety (Tokyo, Japan) · 2025
    Article
  17. Article
  18. Article
  19. Gene profile of virulence, antimicrobial resistance and action of enterocins in Campylobacter species isolated from broiler carcasses.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
    Article
  20. Article

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Lei DaiDepartments of Veterinary Microbiology and Preventive Medicine.
Orhan SahinVeterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa, United States 50011.
Madhusudan GroverDivision of Gastroenterology and Hepatology, Enteric NeuroScience Program, Mayo Clinic, Rochester, Minnesota, United States 55902.
Qijing ZhangDepartments of Veterinary Microbiology and Preventive Medicine. Electronic address: zhang123@iastate.edu.
Iowa State University · USMayo Clinic · US

Funding

Function and inhibition of multidrug efflux systems in CampylobacterR01AI118283 · NIAID · IOWA STATE UNIVERSITY · PI ZHANG, QIJING · 2016 to 2020
$1.6M
"Barrier function alterations in post-infectious irritable bowel syndrome"K23DK103911 · NIDDK · MAYO CLINIC ROCHESTER · PI GROVER, MADHUSUDAN · 2015 to 2019
$804k
Mechanisms of barrier dysfunction in post-infection irritable bowel syndromeR03DK120745 · NIDDK · MAYO CLINIC ROCHESTER · PI GROVER, MADHUSUDAN · 2019 to 2020
$239k
NIAID NIH HHS R01 AI118283NIDDK NIH HHS K23 DK103911NIDDK NIH HHS R03 DK120745
6 · The paper itself

Abstract

Campylobacter is an enteric pathogen and a leading bacterial cause of diarrhea worldwide. It is widely distributed in food animal species and is transmitted to humans primarily through the foodborne route. While generally causing self-limited diarrhea in humans, Campylobacter may induce severe or systemic infections in immunocompromised or young/elderly patients, which often requires antibiotic therapy with the first-line antibiotics including fluoroquinolones and macrolides. Over the past decades, Campylobacter has acquired resistance to these clinically significant antibiotics, compromising the effectiveness of antibiotic treatments. To address this concern, many studies have been conducted to advance novel and alternative measures to control antibiotic-resistant Campylobacter in animal reservoirs and in the human host. Although some of these undertakings have yielded promising results, efficacious and reliable alternative approaches are yet to be developed. In this review article, we will describe Campylobacter-associated disease spectrums and current treatment options, discuss the state of antibiotic resistance and alternative therapies, and provide an evaluation of various approaches that are being developed to control Campylobacter infections in animal reservoirs and the human host.

Indexed as

Drug Resistance, MicrobialAnimalsAnti-Bacterial AgentsCampylobacterCampylobacter InfectionsHumansImmunizationAnti-Bacterial AgentsAntibiotic resistanceCampylobacterControl StrategiesTherapeutics

Identifiers

PMID32438073
PMCPMC7423705
OpenAlexW3022220807

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.