Evidence map›Paper›PMID 32438054›Full record

ReviewMatrix biology : journal of the International Society for Matrix Biology2020

T-cell regulation of fibroblasts and cardiac fibrosis.

Amy D Bradshaw, Kristine Y DeLeon-Pennell

Open access · greenAbstract readReview
In one paragraph

Review in Matrix biology : journal of the International Society for Matrix Biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Cellular and molecular signals of cardiac wound healing after myocardial infarction.American journal of physiology. Heart and circulatory physiology · 2026
    Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Pericytes in tissue fibrosis.American journal of physiology. Cell physiology · 2025
    Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Fibroblasts under pressure: cardiac fibroblast responses to hypertension and antihypertensive therapies.American journal of physiology. Heart and circulatory physiology · 2024
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Regulation of cardiac fibroblasts by lymphocytes after a myocardial infarction: playing in the major league.American journal of physiology. Heart and circulatory physiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Amy D BradshawDepartment of Medicine, Division of Cardiology, Medical University of South Carolina, Ralph H. Johnson Veterans Affairs Medical Center, 109 Bee Street Charleston, SC 29401, United States.
Kristine Y DeLeon-PennellDepartment of Medicine, Division of Cardiology, Medical University of South Carolina, Ralph H. Johnson Veterans Affairs Medical Center, 109 Bee Street Charleston, SC 29401, United States. Electronic address: deleonky@musc.edu.
Medical University of South Carolina · US

Funding

The Impact of Stress and Craving on Return to Postpartum Cannabis UseU54DA016511 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI AIMEE L MCRAE-CLARK, Rachel Lynn Tomko · 2018 to 2026
$15.9M
Training In Cardiovascular Physiology & PharmacologyT32HL007444 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ju Chen, Robert Scott Ross · 1985 to 2026
$11.1M
UCSD PRIDE Faculty Development Program in Cardiovascular SciencesR25HL145817 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Robert Scott Ross, Joann Trejo · 2019 to 2026
$3.3M
Macrophage Expression of SPARC Contributes to Pressure-Overload Dependent Change in Collagen Content and Myocardial StiffnessI01CX001608 · VA · RALPH H JOHNSON VA MEDICAL CENTER · PI BRADSHAW, AMY D, ZILE, MICHAEL R · 2018 to 2021
–
T-cell regulation of cardiac remodelingIK2BX003922 · VA · RALPH H JOHNSON VA MEDICAL CENTER · PI DELEON-PENNELL, KRISTINE Y · 2017 to 2022
–
BLRD VA IK2 BX003922CSRD VA I01 CX001608NHLBI NIH HHS R25 HL145817NHLBI NIH HHS T32 HL007444NIDA NIH HHS U54 DA016511
6 · The paper itself

Abstract

Inflammation contributes to the development of heart failure (HF) through multiple mechanisms including regulating extracellular matrix (ECM) degradation and deposition. Interactions between cells in the myocardium orchestrates the magnitude and duration of inflammatory cell recruitment and ECM remodeling events associated with HF. More recently, studies have shown T-cells have signficant roles in post-MI wound healing. T-cell biology in HF illustrates the complexity of cross-talk between inflammatory cell types and resident fibroblasts. This review will focus on T-cell recruitment to the myocardium and T-cell specific factors that might influence cardiac wound healing and fibrosis in the heart with consideration of age and sex as important factors in T-cell activity.

Indexed as

Age FactorsAntigens, CDCell CommunicationCytokinesEndomyocardial FibrosisExtracellular MatrixFemaleFibroblastsGene Expression RegulationHeart FailureHumansInflammationMacrophagesMaleMyocardial InfarctionMyocardiumAntigens, CDCytokinesAgeFibrosisInflammationMyocardial infarctionSexT-cell

Identifiers

PMID32438054
PMCPMC7434661
OpenAlexW3025104353

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.