ReviewRespiratory physiology & neurobiology2020
Distinct phenotypes require distinct respiratory management strategies in severe COVID-19.
Review in Respiratory physiology & neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 94 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective Clinical Study to Explore the Mechanism of Patients' Response to Prone Positioning in ARDS Patients, Including COVID-19
Epidemiology of Weaning From Invasive Mechanical Ventilation in COVID-19. Observational and Multicenter Study.
Who cites it
94 citing papers in PubMed, 1 synthesis or guideline pooled it, 186 citations in OpenAlex.
- Prone position for acute respiratory failure in adults.The Cochrane database of systematic reviews · 2015Pooled it
- Characterizing heterogeneity and subphenotyping acute respiratory distress syndrome with computed tomography.Intensive care medicine experimental · 2026Review
- Precision Oxygen Therapy in the Intensive Care Unit: Matching Oxygen Exposure to Patient Phenotypes.Journal of personalized medicine · 2026Article
- Utilizing CT chest imaging for the diagnosis and monitoring of COVID infections and emergency intensive care unit strategic treatment.Frontiers in medicine · 2026Article
- Phenotyping COVID-19 respiratory failure in spontaneously breathing patients with AI on lung CT-scan.Critical care (London, England) · 2024Observational
- Clinical Profile and Course of Patients with Acute Respiratory Distress Syndrome due to COVID-19 in a Middle-Income Region in Mexico.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2024Article
- Content analysis of NOC outcomes related to mechanical ventilation in people with COVID-19.Revista da Escola de Enfermagem da U S P · 2024Review
- Editorial: Personalized therapy in ARDS, volume II.Frontiers in medicine · 2024Article
- External validation of unsupervised COVID-19 clinical phenotypes and their prognostic impact.Annals of medicine · 2023Article
- Mortality in a swiftly repurposed hospital in northeast Brazil during the first and second COVID-19 waves: A retrospective cohort study.IJID regions · 2023Article
- Systemic and Cerebral Effects of Physiotherapy in Mechanically Ventilated Subjects.Respiratory care · 2023Observational
- Morphological and functional findings in COVID-19 lung disease as compared to Pneumonia, ARDS, and High-Altitude Pulmonary Edema.Respiratory physiology & neurobiology · 2023Review
- Factors associated with mortality in mechanically ventilated patients with severe acute respiratory syndrome due to COVID-19 evolution.Critical care science · 2023Article
- Regional ventilation in spontaneously breathing COVID-19 patients during postural maneuvers assessed by electrical impedance tomography.Acta anaesthesiologica Scandinavica · 2023Observational
- Article
- New and personalized ventilatory strategies in patients with COVID-19.Frontiers in medicine · 2023Review
- Interpretable clinical phenotypes among patients hospitalized with COVID-19 using cluster analysis.Frontiers in digital health · 2023Article
- Physiological response to prone positioning in intubated adults with COVID-19 acute respiratory distress syndrome: a retrospective study.Respiratory research · 2022Article
- Pulmonary infection by SARS-CoV-2 induces senescence accompanied by an inflammatory phenotype in severe COVID-19: possible implications for viral mutagenesis.The European respiratory journal · 2022Article
- Early versus late intubation in COVID-19 patients failing helmet CPAP: A quantitative computed tomography study.Respiratory physiology & neurobiology · 2022Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coronavirus disease 2019 (COVID-19) can cause severe respiratory failure requiring mechanical ventilation. The abnormalities observed on chest computed tomography (CT) and the clinical presentation of COVID-19 patients are not always like those of typical acute respiratory distress syndrome (ARDS) and can change over time. This manuscript aimed to provide brief guidance for respiratory management of COVID-19 patients before, during, and after mechanical ventilation, based on the recent literature and on our direct experience with this population. We identify that chest CT patterns in COVID-19 may be divided into three main phenotypes: 1) multiple, focal, possibly overperfused ground-glass opacities; 2) inhomogeneously distributed atelectasis; and 3) a patchy, ARDS-like pattern. Each phenotype can benefit from different treatments and ventilator settings. Also, peripheral macro- and microemboli are common, and attention should be paid to the risk of pulmonary embolism. We suggest use of personalized mechanical ventilation strategies based on respiratory mechanics and chest CT patterns. Further research is warranted to confirm our hypothesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.