ArticleThe Journal of pediatrics2020
Adolescent Opioid Misuse Attributable to Adverse Childhood Experiences.
Article in The Journal of pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 53 citations in OpenAlex.
- Strengths-Based Programs for Youth at Risk for Toxic Stress: A Scoping Review of Programs Targeting Mental Health, Substance Use, Parenting Skills, and Family Functioning.Trauma, violence & abuse · 2026Article
- Adverse Effects of Non-Medical Use of Cannabis or Opioids Associated with Adverse Childhood Experiences.International journal of environmental research and public health · 2026Article
- Evaluating the Combined Effects of an Adverse Childhood Experiences-Focused Family Advocate Model and the Strengthening Families Program: Study Protocol for a Hybrid Type 1 Effectiveness-Implementation Trial in 36 New Jersey Communities.JMIR research protocols · 2026Article
- Effects of acute adolescent stress on the acquisition and maintenance of intravenous oxycodone self-administration in male and female rats.Drug and alcohol dependence · 2026Article
- Effects of acute adolescent stress on the acquisition and maintenance of intravenous oxycodone self-administration in male and female rats.bioRxiv : the preprint server for biology · 2025Article
- The Impact of Adversity and Family Conflict on Risk for Future Substance Use Among Young Adolescents in the Adolescent Brain Cognitive Development Study (ABCD Study): A Cohort Analysis.Journal of child and adolescent psychiatric nursing : official publication of the Association of Child and Adolescent Psychiatric Nurses, Inc · 2025Article
- Adolescents' Adverse Childhood Experiences, Poor Mental Health, and Substance Use During the COVID-19 Pandemic.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2025Article
- Association Between Self-Reported Opioid Use and Behavioral/Social Health Characteristics-Arizona, 2020.International journal of mental health and addiction · 2025Article
- Modulating mechanisms of adverse childhood experiences in a mindfulness-based intervention: preliminary insights from an opioid use disorder study.Frontiers in psychology · 2025Article
- Online Delivery of Interprofessional Adverse Childhood Experiences Training to Rural Providers: Usability Study.JMIR pediatrics and parenting · 2024Article
- Adverse Childhood Experiences in Brazilian College Students: Examining Associations with Suicidal Ideation and Risky Behaviors.Journal of child & adolescent trauma · 2024Article
- Enhancing the Focus: How Does Parental Incarceration Fit into the Overall Picture of Adverse Childhood Experiences (ACEs) and Positive Childhood Experiences (PCEs)?Research on child and adolescent psychopathology · 2023Article
- Immunoassay Urine Drug Testing among Patients Receiving Opioids at a Safety-Net Palliative Medicine Clinic.Cancers · 2023Article
- Psychosocial Correlates of Opioid Use Profiles among Young Adults in a Longitudinal Study across 6 US Metropolitan Areas.Substance use & misuse · 2023Article
- Sex differences in the association of adverse childhood experiences on past 30-day opioid misuse among Florida justice-involved children.Journal of substance abuse treatment · 2022Article
- Poly-victimization and opioid use during late adolescence and young adulthood: Health behavior disparities and protective factors.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2022Article
- Adverse Childhood Experiences and Overdose: Lessons From Overdose Data to Action.American journal of preventive medicine · 2022Article
- Methamphetamine use in the United States: epidemiological update and implications for prevention, treatment, and harm reduction.Annals of the New York Academy of Sciences · 2022Review
- Adverse childhood experiences and traumatic brain injury among adolescents: findings from the 2016-2018 National Survey of Children's Health.European child & adolescent psychiatry · 2022Article
- Association of Online Risk Factors With Subsequent Youth Suicide-Related Behaviors in the US.JAMA network open · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 7 institutions in 1 country.
Funding
Abstract
objectivesTo estimate the proportion of opioid misuse attributable to adverse childhood experiences (ACEs) among adolescents. STUDY
designA cross-sectional survey was administered to 10 546 seventh-to twelfth-grade students in northeastern Ohio in Spring 2018. Study measures included self-reported lifetime exposure to 10 ACEs and past 30-day use of nonmedical prescription opioid or heroin. Using generalized estimating equations, we evaluated associations between recent opioid misuse, individual ACEs, and cumulative number of ACEs. We calculated population attributable fractions to determine the proportion of adolescents' recent opioid misuse attributable to ACEs.
resultsNearly 1 in 50 adolescents reported opioid misuse within 30 days (1.9%); approximately 60% of youth experienced ≥1 ACE; 10.2% experienced ≥5 ACEs. Cumulative ACE exposure demonstrated a significant graded relationship with opioid misuse. Compared with youth with zero ACEs, youth with 1 ACE (aOR 1.9, 95% CI, 0.9-3.9), 2 ACEs (aOR, 3.8; 95% CI, 1.9-7.9), 3 ACEs (aOR, 3.7; 95% CI, 2.2-6.5), 4 ACEs (aOR, 5.8; 95% CI, 3.1-11.2), and ≥5 ACEs (aOR, 15.3; 95% CI, 8.8-26.6) had higher odds of recent opioid misuse. The population attributable fraction of recent opioid misuse associated with experiencing ≥1 ACE was 71.6% (95% CI, 59.8-83.5).
conclusionsThere was a significant graded relationship between number of ACEs and recent opioid misuse among adolescents. More than 70% of recent adolescent opioid misuse in our study population was attributable to ACEs. Efforts to decrease opioid misuse could include programmatic, policy, and clinical practice interventions to prevent and mitigate the negative effects of ACEs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.