Evidence map›Paper›PMID 32437626›Full record

Trial reportJDR clinical and translational research2021

Addition of Povidone-Iodine to Fluoride Varnish for Dental Caries: A Randomized Clinical Trial.

P Milgrom, O Tut, M Rothen, L Mancl, M Gallen, J M Tanzer

2 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in JDR clinical and translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03082196 phase2completednot on this map

Phase 2 Efficacy Evaluation Of Advantage Anti-Caries Varnish

TypeinterventionalSponsorAdvantage Dental Services, LLCRan2017 to 2019Enrolled284ConditionsDental CariesArmsTest varnish, Standard varnish
NCT07741409 phase3not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Povidone Iodine to Prevent Early Childhood Caries

TypeinterventionalSponsorJeffrey A. BanasRan2026 to 2028Enrolled174ConditionsDental CariesArmsPovidone Iodine 5% Soln,Top,Kit, Probiotics, Placebo
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

P MilgromDepartment of Oral Health Sciences, School of Dentistry, University of Washington, Seattle, WA, USA.ORCID 0000-0003-0784-9181
O TutDepartment of Oral Health Sciences, School of Dentistry, University of Washington, Seattle, WA, USA.
M RothenRegional Clinical Dental Research Center, Institute of Translational Health Sciences, University of Washington, Seattle, WA, USA.
L ManclDepartment of Oral Health Sciences, School of Dentistry, University of Washington, Seattle, WA, USA.
M GallenDepartment of Dental Services, Pohnpei State Department of Health Services, Kolonia, Federated States of Micronesia.
J M TanzerDepartment of Oral and Maxillofacial Diagnostic Sciences, University of Connecticut Health, Farmington, CT, USA.
University of Washington · USMicronesia Conservation Trust · FMUConn Health · US

Funding

Transform Dissemination and Implementation Science in CTSA ProgramsUL1TR002319 · NCATS · UNIVERSITY OF WASHINGTON · PI John K. Amory · 2017 to 2026
$100.0M
Phase II RCT of Advantage Anti-Cavity VarnishR44DE022986 · NIDCR · ADP SILVER DENTAL ARREST, LLC · PI MILGROM, PETER M, SHIRTCLIFF, R MIKE · 2016 to 2016
$150k
NCATS NIH HHS UL1 TR002319NIDCR NIH HHS R44 DE022986
6 · The paper itself

Abstract

introductionDental caries is the most common chronic childhood disease. Products of metabolism by bacteria populating the tooth surface induce development and progression of cavities.

objectivesWe sought to determine whether a polyvinylpyrrolidone-iodine (PVP-I; povidone-iodine) and NaF topical varnish was superior to one containing only NaF in prevention of new dental caries lesions in a single-center randomized active-controlled trial based on a double-blind, parallel-group design.

methodsThe site was Pohnpei State, Federated States of Micronesia. The study population was healthy children 49 to 84 mo old who were enrolled in early childhood education: 284 were randomized (1:1 allocation), and 273 were included in year 1 analysis and 262 in year 2. The test varnish contained 10% PVP-I and 5.0% NaF. The comparator contained only 5.0% NaF but was otherwise identical. Varnishes were applied every 3 mo during 2 y. The primary outcome was the surface-level primary molar caries lesion increment (d

resultsAt year 1, the caries lesion increment for primary molars sound at baseline was 0.9 surfaces (SD = 1.5) for the test varnish versus 1.8 (SD = 2.2) for the comparator varnish with fluoride alone (adjusted rate ratio, 0.50; 95% CI, 0.31 to 0.81; P = .005). At year 2, the caries lesion increment for primary molars sound at baseline was 2.3 surfaces (SD = 2.8) for the test varnish as compared with 3.3 (SD = 2.7) for the comparator (adjusted rate ratio, 0.74; 95% CI, 0.52 to 1.03; P = .073). Teeth that were already cavitated at baseline did not show a preventive effect. There were no harms.

conclusionsA dental varnish containing PVP-I and NaF is effective in the primary prevention of cavities in the primary dentition (NCT03082196). KNOWLEDGE TRANSFER STATEMENT: This study demonstrates that periodic application of a varnish containing NaF and PVP-I is effective in prevention of caries lesions and useful in assessing the potential of combined treatment.

Indexed as

Dental CariesPovidone-IodineCariostatic AgentsChildChild, PreschoolFluoridesFluorides, TopicalHumansMicronesiaCariostatic AgentsFluoridesFluorides, TopicalPovidone-Iodineanti-infective agents localchilddrug monitoringMicronesiasodium fluoride topical preparationtherapeutic use

Identifiers

PMID32437626
PMCPMC7970344
OpenAlexW3026162124

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.