Evidence map›Paper›PMID 32437590›Full record

ArticleCancer science2020

Peripubertal high-fat diet promotes c-Myc stabilization in mammary gland epithelium.

Nilakshi Kulathunga, Susumu Kohno, Paing Linn, Yuuki Nishimoto, Shin-Ichi Horike, Mikhail I Zaraiskii, Sharad Kumar, Hayato Muranaka, Chiaki Takahashi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. TargetingCancers · 2021
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 4 countries.

Nilakshi KulathungaDivision of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Susumu KohnoDivision of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Paing LinnDivision of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Yuuki NishimotoDivision of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Shin-Ichi HorikeAdvanced Science Research Center, Kanazawa University, Kanazawa, Japan.
Mikhail I ZaraiskiiPavlov First St. Petersburg State Medical University, St. Petersburg, Russia.
Sharad KumarCentre for Cancer Biology, University of South Australia, Adelaide, SA, Australia.
Hayato MuranakaDivision of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Chiaki TakahashiDivision of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.ORCID https://orcid.org/0000-0003-3390-9563
Kanazawa University · JPFirst Pavlov State Medical University of St. Petersburg · RUUniversity of South Australia · AU

Funding

THE INTEGRATIVE FUNCTION OF THE THALAMUSF05TW003509 · FIC · NEW YORK STATE PSYCHIATRIC INSTITUTE · PI FAVILLA, MARCO · 1985 to 1985
–
AMED-CREST 20gm0910003h0206Funding Program for Next Generation World-Leading Researchers LS049Grants-in-Aid for Scientific Research 17H03576Grants-in-Aid for Scientific Research 17K19586Grants-in-Aid for Scientific Research 19K22555Grants-in-Aid for Scientific Research 20H03509Grants-in-Aid for Scientific Research on Innovative Areas 15H01487Grants-in-Aid for Scientific Research on Innovative Areas 17H05615NHMRC Senior Principal Research Fellowship GNT1103006
6 · The paper itself

Abstract

Dietary fat consumption during accelerated stages of mammary gland development, such as peripubertal maturation or pregnancy, is known to increase the risk for breast cancer. However, the underlying molecular mechanisms are not fully understood. Here we examined the gene expression profile of mouse mammary epithelial cells (MMECs) on exposure to a high-fat diet (HFD) or control diet (CD). Trp53

Indexed as

Diet, High-FatSexual MaturationAnimalsCell Line, TumorEpitheliumFemaleGenes, p53HumansMammary Glands, AnimalMiceMice, KnockoutObesityProto-Oncogene Proteins c-mycPubertyTumor Cells, CulturedProto-Oncogene Proteins c-mycbreast cancerc-Mychigh-fat dietmammary glandoleic acid

Identifiers

PMID32437590
PMCPMC7385354
OpenAlexW3026384108

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.