Evidence map›Paper›PMID 32437303›Full record

ReviewCirculation research2020

Treatment of Obesity in Mitigating Metabolic Risk.

Sean P Heffron, Johnathon S Parham, Jay Pendse, José O Alemán

Erratum issuedOpen access · greenAbstract readReview
In one paragraph

Review in Circulation research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 39 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  7. Review
  8. Effects of a Short-Term Nutritional Intervention on Vascular Changes in Individuals with Obesity and Low or Moderate Cardiovascular Health.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026
    Article
  9. Exercise benefits in metabolism on cardiovascular disease.Frontiers in cardiovascular medicine · 2026
    Review
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  12. Observational
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sean P HeffronFrom the Leon H. Charney Division of Cardiology (S.P.H.), NYU Grossman School of Medicine, New York.
Johnathon S ParhamNYU Center for the Prevention of Cardiovascular Disease (S.P.H., J.S.P.), NYU Grossman School of Medicine, New York.
Jay PendseDivision of Endocrinology, Department of Medicine (J.P., J.O.A.), NYU Grossman School of Medicine, New York.
José O AlemánDivision of Endocrinology, Department of Medicine (J.P., J.O.A.), NYU Grossman School of Medicine, New York.
New York University · USVA NY Harbor Healthcare System · US

Funding

Training Program in Cardiovascular SciencesT32HL098129 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Glenn I Fishman, Ira J Goldberg · 2009 to 2026
$5.9M
Metabolic Flux Analysis of Obesity-Associated Inflammation in Weight LossK08DK117064 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ALEMAN, JOSE ORLANDO · 2019 to 2022
$823k
Effects of Bariatric Surgery on HDL and Platelet FunctionK23HL135398 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI HEFFRON, SEAN PATRICK · 2017 to 2021
$764k
NHLBI NIH HHS K23 HL135398NHLBI NIH HHS T32 HL098129NIDDK NIH HHS K08 DK117064
6 · The paper itself

Abstract

Through diverse mechanisms, obesity contributes to worsened cardiometabolic health and increases rates of cardiovascular events. Effective treatment of obesity is necessary to reduce the associated burdens of diabetes mellitus, cardiovascular disease, and death. Despite increasing cardiovascular outcome data on obesity interventions, only a small fraction of the population with obesity are optimally treated. This is a primary impetus for this article in which we describe the typical weight loss, as well as the associated impact on both traditional and novel cardiovascular disease risk factors, provided by the 4 primary modalities for obtaining weight loss in obesity-dietary modification, increasing physical activity, pharmacotherapy, and surgery. We also attempt to highlight instances where changes in metabolic risk are relatively specific to particular interventions and appear at least somewhat independent of weight loss. Finally, we suggest important areas for further research to reduce and prevent adverse cardiovascular consequences due to obesity.

Indexed as

AnimalsAnti-Obesity AgentsBariatric SurgeryCaloric RestrictionExercise TherapyHumansMetabolic SyndromeObesityAnti-Obesity Agentscardiovascular diseaseexerciseobesityrisk factorweight loss

Identifiers

PMID32437303
PMCPMC7343291
OpenAlexW3027956462

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.