ReviewJournal of applied physiology (Bethesda, Md. : 1985)2020
Let's talk about sex in the context of COVID-19.
Review in Journal of applied physiology (Bethesda, Md. : 1985), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 73 citations in OpenAlex.
- Association between vaccination status and clinical characteristics among young adults infected with COVID-19.BMC infectious diseases · 2025Article
- Sex-specific disparities in COVID-19 outcomes.Journal of the American College of Emergency Physicians open · 2024Article
- SARS-CoV-2 mucosal vaccine protects against clinical disease with sex bias in efficacy.Vaccine · 2024Article
- Radiological features of COVID-19-associated mucormycosis: A report of 36 cases along with a literature review.Clinical case reports · 2023Article
- Article
- Long-lasting cognitive effects of COVID-19: is there a role of BDNF?European archives of psychiatry and clinical neuroscience · 2023Article
- Syndemic aspects between COVID-19 pandemic and social inequalities.World journal of methodology · 2022Review
- Depressive symptoms and other negative psychological states relate to ex vivo inflammatory responses differently for men and women: Cross-sectional and longitudinal evidence.Physiology & behavior · 2022Article
- Sex-differences in COVID-19 diagnosis, risk factors and disease comorbidities: A large US-based cohort study.Frontiers in public health · 2022Article
- Sex hormones and immune system: Menopausal hormone therapy in the context of COVID-19 pandemic.Frontiers in immunology · 2022Review
- Epidemiology, Clinico-Pathological Characteristics, and Comorbidities of SARS-CoV-2-Infected Pakistani Patients.Frontiers in cellular and infection microbiology · 2022Article
- Feminising hormone therapy reduces testicular ACE-2 receptor expression: Implications for treatment or prevention of COVID-19 infection in men.Andrologia · 2021Article
- Risk Factors for COVID-19 Morbidity and Mortality in Institutionalised Elderly People.International journal of environmental research and public health · 2021Article
- The Emergence of SARS-CoV-2 within the Dog Population in Croatia: Host Factors and Clinical Outcome.Viruses · 2021Article
- Complement Decay-Accelerating Factor is a modulator of influenza A virus lung immunopathology.PLoS pathogens · 2021Article
- Review
- Analysis of COVID-19 pandemics in Kazakhstan.Journal of research in health sciences · 2021Article
- Diverse Immunological Factors Influencing Pathogenesis in Patients with COVID-19: A Review on Viral Dissemination, Immunotherapeutic Options to Counter Cytokine Storm and Inflammatory Responses.Pathogens (Basel, Switzerland) · 2021Review
- Early mortality in hip fracture patients admitted during first wave of the COVID-19 pandemic in Northern Italy: a multicentre study.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2021Article
- Distinct expression of SARS-CoV-2 receptor ACE2 correlates with endotypes of chronic rhinosinusitis with nasal polyps.Allergy · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent months, the coronavirus disease 2019 (COVID-19) pandemic has sent many countries into crisis. Studies have shown that this virus causes worse outcomes and a higher mortality in men than in women. It has been recognized that sex can affect the immune response to a pathogenic agent, as well as the susceptibility for some respiratory diseases. These different responses in males and females may be related to the actions of sex hormones. Angiotensin-converting enzyme 2 (ACE2) acts as the receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19. The expression of ACE2 is influenced by sex hormones; therefore, we discuss in this article that this could be one of the reasons why COVID-19 is more prevalent in men than in women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.