Evidence map›Paper›PMID 32437125›Full record

ArticleAnalytical chemistry2020

Dual-Readout Sandwich Immunoassay for Device-Free and Highly Sensitive Anthrax Biomarker Detection.

Isaac N Larkin, Viswanadham Garimella, Gokay Yamankurt, Alexander W Scott, Hang Xing, Chad A Mirkin

Abstract read
In one paragraph

Article in Analytical chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Isaac N LarkinInternational Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60608, United States.ORCID 0000-0002-5750-2437
Viswanadham GarimellaInternational Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60608, United States.
Gokay YamankurtInternational Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60608, United States.
Alexander W ScottInternational Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60608, United States.
Hang XingInternational Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60608, United States.ORCID 0000-0003-3917-8343
Chad A MirkinInternational Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60608, United States.ORCID 0000-0002-6634-7627

Funding

CELLULAR &MOLECULAR BASIS OF DISEASE TRAINING PROGRAMT32GM008061 · NIGMS · NORTHWESTERN UNIVERSITY · PI CARTHEW, RICHARD W. · 1985 to 2022
$17.1M
Project 3: Spherical Nucleic Acids as Immunotherapeutic Agents for Prostate CancerU54CA199091 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MIRKIN, CHAD A. · 2015 to 2019
$11.7M
Theranostic Magnetic Nanostructures for the Molecular Imaging of CancerU54CA151880 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MIRKIN, CHAD A. · 2010 to 2014
$11.5M
Chemistry of Life Processes Predoctoral Training ProgramT32GM105538 · NIGMS · NORTHWESTERN UNIVERSITY · PI KELLEHER, NEIL L · 2013 to 2022
$2.7M
NCI NIH HHS U54 CA151880NCI NIH HHS U54 CA199091NIGMS NIH HHS T32 GM008061NIGMS NIH HHS T32 GM105538
6 · The paper itself

Abstract

We report a dual-readout, AuNP-based sandwich immunoassay for the device-free colorimetric and sensitive scanometric detection of disease biomarkers. An AuNP-antibody conjugate serves as a signal transduction and amplification agent by promoting the reduction and deposition of either platinum or gold onto its surface, generating corresponding colorimetric or light scattering (scanometric) signals, respectively. We apply the Pt-based colorimetric readout of this assay to the discovery of a novel monoclonal antibody (mAb) sandwich pair for the detection of an anthrax protective antigen (PA

Indexed as

ImmunoassayAnthraxAntibodies, MonoclonalAntigens, BacterialBacterial ToxinsBiomarkersColorimetryGoldMetal Nanoparticlesanthrax toxinAntibodies, MonoclonalAntigens, BacterialBacterial ToxinsBiomarkersGold

Identifiers

PMID32437125
PMCPMC7418077

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.