The potential of memantine and related adamantanes such as amantadine, to reduce the neurotoxic effects of COVID-19, including ARDS and to reduce viral replication through lysosomal effects.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

11 citing papers in PubMed, 30 citations in OpenAlex.

1. Amantadine in unvaccinated patients with early, mild to moderate COVID-19: A randomized, placebo-controlled, double-blind trial.European journal of neurology · 2024
   Trial
2. Novel adamantyl clubbed iminothiazolidinones as promising elastase inhibitors: design, synthesis, molecular docking, ADMET and DFT studies.RSC advances · 2022
   Article
3. Determination of Ligand Binding Modes in Hydrated Viral Ion Channels to Foster Drug Design and Repositioning.Journal of chemical information and modeling · 2021
   Article
4. Neurological involvement in the respiratory manifestations of COVID-19 patients.Aging · 2021
   Review
5. Direct and indirect neurological, cognitive, and behavioral effects of COVID-19 on the healthy elderly, mild-cognitive-impairment, and Alzheimer's disease populations.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
   Review
6. Amantadine: reappraisal of the timeless diamond-target updates and novel therapeutic potentials.Journal of neural transmission (Vienna, Austria : 1996) · 2021
   Review
7. Use of amantadine in a patient with SARS-CoV-2.Journal of medical virology · 2021
   Article
8. A retrospective review of memantine use and COVID-19-associated mortality from a national database.Journal of medical virology · 2021
   Article
9. Clinical Characteristics of Coronavirus Disease 2019 (COVID-19) among Patients at a Movement Disorders Center.Geriatrics (Basel, Switzerland) · 2020
   Article
10. Underlying Mechanisms and Candidate Drugs for COVID-19 Based on the Connectivity Map Database.Frontiers in genetics · 2020
    Article
11. COVID-19 and Dementia; Hard to Forget Yet Haunting Forgetfulness!Annals of Indian Academy of Neurology
    Article

Corrections and comments

• Commented on by
  A retrospective review of memantine use and COVID-19-associated mortality from a national database.2021
• Comment on
  The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients.2020

Authors and funding

1 author at 1 institution in 1 country.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as