Trial reportThe British journal of radiology2020
Minimizing contrast media dose in CT pulmonary angiography with high-pitch technique.
Trial report in The British journal of radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- Vascular attenuation and volumetric lung iodine density in dual-layer spectral CT pulmonary angiography: a randomized controlled trial comparing three contrast doses.European radiology · 2026Trial
- A randomised controlled trial comparing three clinical administration strategies in spectral detector CT pulmonary angiography with low contrast medium dose.European radiology · 2025Trial
- Impact of arm position on low dose dual-source CT one-step aortic and cerebral-carotid artery angiography image quality and radiation dose.BMC medical imaging · 2025Trial
- Individualized Scan Protocol Based on Body Mass Index in Dual-Energy Computed Tomography Pulmonary Angiography to Reduce Radiation and Contrast Doses with Improved Image Quality.Medical science monitor : international medical journal of experimental and clinical research · 2023Trial
- Feasibility of reducing radiation dose and contrast dose while improving image quality in dual-energy CT pulmonary angiography : Use of low-energy virtual monochromatic images with deep learning image reconstruction algorithm.Radiologie (Heidelberg, Germany) · 2026Article
- Computed tomography pulmonary angiography in around-the-clock clinical care with individualised scan protocols: a 5-year observational study on incidence and causes of repeat scanning.European radiology · 2026Observational
- Reducing contrast media dosage for pulmonary embolism CTPA in PCD-CT: a comparative study of EID-CT and PCD-CT in the era of individualized protocolling.European radiology · 2026Article
- Low KV-low contrast medium dose one-stop dual source CT high pitch integrated coronary-carotid-cerebral-aortic CTA improves image quality and reduces both radiation and contrast medium doses.European journal of radiology open · 2025Article
- Acute Pulmonary Embolism: Prognostic Role of Computed Tomography Pulmonary Angiography (CTPA).Tomography (Ann Arbor, Mich.) · 2022Review
- Optimizing low contrast volume thoracic CT angiography: From the basics to the advanced.Journal of clinical imaging science · 2022Article
- Comparative Study of Diagnostic Efficacy of Single Phase-Computed Tomography Pulmonary Angiography and Dual Phase-Computed Tomography Pulmonary Angiography in the Diagnosis of Pulmonary Embolism.Frontiers in cardiovascular medicine · 2022Article
- The ultrafast, high-pitch turbo FLASH mode of third-generation dual-source CT: Effect of different pitch and corresponding SFOV on image quality in a phantom study.Journal of applied clinical medical physics · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo perform CT pulmonary angiography (CTPA) using a minimal amount of iodinated contrast media.
methods47 patients (25 females) with mean age 69 years (range 41-82 years) referred for contrast-enhanced chest CT were prospectively included in this Phase IV clinical drug trial. All participants underwent a study specific CTPA in addition to the chest CT. The participants received 80 mg I/kg body weight Iohexol contrast media using a preparatory saline bolus, a dual flow contrast/saline bolus and a saline flush, and a scanner protocol with 80 kVp dual source high-pitch mode. Three readers independently assessed the image quality on the 3-point scale non-diagnostic, adequate or good-excellent image quality. Additionally, the pulmonary arterial contrast opacification was measured.
resultsOn average, the patients received 16.8 ml Iohexol 350 mg I/mL (range 12-20 ml). Mean patient weight was 71 kg (range 50-85 kg). Identically for all readers, pulmonary embolism (PE) was detected in 1/47 participants. The median number of examinations visually scored concerning pulmonary embolism as good-excellent was 47/47 (range 44-47); adequate 0/47 (0-3) and non-diagnostic 0/47 (range 0-0). The proportion adequate or better examinations was for all readers 47/47, 100% [95% confidence interval 92-100%]. The mean attenuation ± standard deviation in the pulmonary trunk was 325 ± 72 Hounsfield unit (range 165-531 Hounsfield unit).
conclusionsDiagnostic CTPA with 17 ml contrast media is possible in non-obese patients using low kVp, high pitch and carefully designed contrast media administration. ADVANCES IN KNOWLEDGE: By combining several procedures in a CTPA protocol, the contrast media dose can be minimized.
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