Evidence map›Paper›PMID 32436671›Full record

ArticleJournal of psychiatry & neuroscience : JPN2020

Association between functional and structural connectivity of the corticostriatal network in people with schizophrenia and unaffected first-degree relatives.

Peng Li, Ri-Xing Jing, Rong-Jiang Zhao, Le Shi, Hong-Qiang Sun, Zengbo Ding, Xiao Lin, Lin Lu, Yong Fan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Altered Brain-Behavior Association During Resting State is a Potential Psychosis Risk Marker.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. The Risk for Schizophrenia-Bipolar Spectrum: Does the Apple Fall Close to the Tree? A Narrative Review.International journal of environmental research and public health · 2023
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Biomarkers in schizophrenia - past, present and future.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Peng LiFrom the Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), and National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, China (Li, Shi, Sun, Lin, Lu); the National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China (Jing); the University of Chinese Academy of Sciences, Beijing, China (Jing); the Department of Alcohol and Drug Dependence, Beijing Hui-Long-Guan Hospital, Peking University, Beijing, China (Zhao); the National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing, China (Ding); the Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China (Lin, Lu); and the Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA (Fan).
Ri-Xing JingFrom the Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), and National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, China (Li, Shi, Sun, Lin, Lu); the National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China (Jing); the University of Chinese Academy of Sciences, Beijing, China (Jing); the Department of Alcohol and Drug Dependence, Beijing Hui-Long-Guan Hospital, Peking University, Beijing, China (Zhao); the National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing, China (Ding); the Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China (Lin, Lu); and the Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA (Fan).
Rong-Jiang ZhaoFrom the Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), and National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, China (Li, Shi, Sun, Lin, Lu); the National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China (Jing); the University of Chinese Academy of Sciences, Beijing, China (Jing); the Department of Alcohol and Drug Dependence, Beijing Hui-Long-Guan Hospital, Peking University, Beijing, China (Zhao); the National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing, China (Ding); the Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China (Lin, Lu); and the Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA (Fan).
Le ShiFrom the Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), and National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, China (Li, Shi, Sun, Lin, Lu); the National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China (Jing); the University of Chinese Academy of Sciences, Beijing, China (Jing); the Department of Alcohol and Drug Dependence, Beijing Hui-Long-Guan Hospital, Peking University, Beijing, China (Zhao); the National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing, China (Ding); the Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China (Lin, Lu); and the Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA (Fan).
Hong-Qiang SunFrom the Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), and National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, China (Li, Shi, Sun, Lin, Lu); the National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China (Jing); the University of Chinese Academy of Sciences, Beijing, China (Jing); the Department of Alcohol and Drug Dependence, Beijing Hui-Long-Guan Hospital, Peking University, Beijing, China (Zhao); the National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing, China (Ding); the Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China (Lin, Lu); and the Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA (Fan).
Zengbo DingFrom the Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), and National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, China (Li, Shi, Sun, Lin, Lu); the National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China (Jing); the University of Chinese Academy of Sciences, Beijing, China (Jing); the Department of Alcohol and Drug Dependence, Beijing Hui-Long-Guan Hospital, Peking University, Beijing, China (Zhao); the National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing, China (Ding); the Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China (Lin, Lu); and the Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA (Fan).
Xiao LinFrom the Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), and National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, China (Li, Shi, Sun, Lin, Lu); the National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China (Jing); the University of Chinese Academy of Sciences, Beijing, China (Jing); the Department of Alcohol and Drug Dependence, Beijing Hui-Long-Guan Hospital, Peking University, Beijing, China (Zhao); the National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing, China (Ding); the Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China (Lin, Lu); and the Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA (Fan).
Lin LuFrom the Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), and National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, China (Li, Shi, Sun, Lin, Lu); the National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China (Jing); the University of Chinese Academy of Sciences, Beijing, China (Jing); the Department of Alcohol and Drug Dependence, Beijing Hui-Long-Guan Hospital, Peking University, Beijing, China (Zhao); the National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing, China (Ding); the Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China (Lin, Lu); and the Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA (Fan).
Yong FanFrom the Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), and National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, China (Li, Shi, Sun, Lin, Lu); the National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China (Jing); the University of Chinese Academy of Sciences, Beijing, China (Jing); the Department of Alcohol and Drug Dependence, Beijing Hui-Long-Guan Hospital, Peking University, Beijing, China (Zhao); the National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing, China (Ding); the Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China (Lin, Lu); and the Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA (Fan).

Funding

Personalized Functional Network Modeling to Characterize and Predict Psychopathology in YouthR01EB022573 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Yong Fan, Theodore Satterthwaite · 2016 to 2026
$6.0M
NIBIB NIH HHS R01 EB022573
6 · The paper itself

Abstract

Background: Dysfunction of the corticostriatal network has been implicated in the pathophysiology of schizophrenia, but findings are inconsistent within and across imaging modalities. We used multimodal neuroimaging to analyze functional and structural connectivity in the corticostriatal network in people with schizophrenia and unaffected first-degree relatives. Methods: We collected resting-state functional magnetic resonance imaging and diffusion tensor imaging scans from people with schizophrenia (n = 47), relatives (n = 30) and controls (n = 49). We compared seed-based functional and structural connectivity across groups within striatal subdivisions defined a priori. Results: Compared with controls, people with schizophrenia had altered connectivity between the subdivisions and brain regions in the frontal and temporal cortices and thalamus; relatives showed different connectivity between the subdivisions and the right anterior cingulate cortex (ACC) and the left precuneus. Post-hoc t tests revealed that people with schizophrenia had decreased functional connectivity in the ventral loop (ventral striatum-right ACC) and dorsal loop (executive striatum-right ACC and sensorimotor striatum-right ACC), accompanied by decreased structural connectivity; relatives had reduced functional connectivity in the ventral loop and the dorsal loop (right executive striatum-right ACC) and no significant difference in structural connectivity compared with the other groups. Functional connectivity among people with schizophrenia in the bilateral ventral striatum-right ACC was correlated with positive symptom severity. Limitations: The number of relatives included was moderate. Striatal subdivisions were defined based on a relatively low threshold, and structural connectivity was measured based on fractional anisotropy alone. Conclusion: Our findings provide insight into the role of hypoconnectivity of the ventral corticostriatal system in people with schizophrenia.

Indexed as

Cerebral CortexConnectomeCorpus StriatumMagnetic Resonance ImagingNerve NetSchizophreniaAdultDiffusion Tensor ImagingFamilyFemaleGyrus CinguliHumansMaleVentral StriatumYoung Adult

Identifiers

PMID32436671
PMCPMC7595738

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.