Evidence map›Paper›PMID 32436660›Full record

ArticleCNS neuroscience & therapeutics2020

Efforts of subthalamic nucleus deep brain stimulation on cognitive spectrum: From explicit to implicit changes in the patients with Parkinson's disease for 1 year.

ZhiFei You, Yi-Ying Wu, Rong Wu, Zhi-Xiang Xu, Xi Wu, Xiao-Ping Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 5 pooled it
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 5 syntheses or guidelines pooled it, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

ZhiFei YouDepartment of Neurology, Shanghai General Hospital of Nanjing Medical University, Shanghai, China.
Yi-Ying WuDepartment of Neurology, Shanghai General Hospital of Nanjing Medical University, Shanghai, China.
Rong WuDepartment of Neurology, Shanghai General Hospital of Nanjing Medical University, Shanghai, China.
Zhi-Xiang XuDepartment of Neurology, Shanghai General Hospital of Nanjing Medical University, Shanghai, China.
Xi WuDepartment of Neurosurgery, Changhai Hospital, The Second Military Medical University, Shanghai, China.
Xiao-Ping WangDepartment of Neurology, Shanghai General Hospital of Nanjing Medical University, Shanghai, China.ORCID 0000-0002-2936-5877
Shanghai Medical College of Fudan University · CNSecond Military Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the cognitive function of Chinese patients with Parkinson's disease PD postsubthalamic nucleus deep brain stimulation (STN-DBS).

methodsCognitive function was assessed by neuropsychological methods in PD patients. Twenty matched healthy persons served as normal controls. t test, analysis of variance, and chi-square analysis were used to compare the difference among the groups. Reliable change index was utilized to analyze the changes in cognition from the individual level.

results(a) Improvement in motor function was significantly better after STN-DBS (P < .01). (b) Notably, the increase error rates of implicit SRTT (serial reaction time task) was significantly higher after STN-DBS as compared with the conservative therapy group (P = .03). (c) The decline of verbal fluency (explicit) was also significantly higher after STN-DBS than that in the medication therapy group (P = .03). (d) In the explicit clock-drawing test, scores had significantly improved after STN-DBS (P = .04).

conclusionsSTN-DBS as a neuromodulatory tool in the Chinese PD population not only improves motor symptoms but also cognitive function to a certain extent, such as the decline of executive function and verbal fluency. The explicit cognitive decline was significantly quicker than that in patients on medication therapy. The improvement of visiospatial function was also noted. Implicit memory impairment during the 1-year follow-up period was not observed.

Indexed as

AgedChinaCognitionCognitive DysfunctionDeep Brain StimulationExecutive FunctionFemaleFollow-Up StudiesHumansMaleMiddle AgedMotor SkillsParkinson DiseaseSubthalamic NucleusTime FactorsTreatment Outcomecognitive functiondeep brain stimulationexplicit memoryimplicit memoryneuromodulatoryParkinson's diseasesubthalamic nucleus

Identifiers

PMID32436660
PMCPMC7415202
OpenAlexW3027322482

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.