Evidence map›Paper›PMID 32436653›Full record

ArticleESC heart failure2020

Unmasking features of the auto-epitope essential for β

Angela Wölfel, Mathias Sättele, Christina Zechmeister, Viacheslav O Nikolaev, Martin J Lohse, Fritz Boege, Roland Jahns, Valérie Boivin-Jahns

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Angela WölfelInstitute of Pharmacology and Toxicology, University of Würzburg, Versbacher Str. 9, D-97078, Wuerzburg, Germany.
Mathias SätteleInstitute of Pharmacology and Toxicology, University of Würzburg, Versbacher Str. 9, D-97078, Wuerzburg, Germany.
Christina ZechmeisterInstitute of Pharmacology and Toxicology, University of Würzburg, Versbacher Str. 9, D-97078, Wuerzburg, Germany.
Viacheslav O NikolaevInstitute of Pharmacology and Toxicology, University of Würzburg, Versbacher Str. 9, D-97078, Wuerzburg, Germany.
Martin J LohseInstitute of Pharmacology and Toxicology, University of Würzburg, Versbacher Str. 9, D-97078, Wuerzburg, Germany.
Fritz BoegeRudolf-Virchow-Centre, Institute of Clinical Chemistry and Laboratory Diagnostics, University Hospital, Moorenstraße 5, 40225, Düsseldorf, Germany.
Roland JahnsInstitute of Pharmacology and Toxicology, University of Würzburg, Versbacher Str. 9, D-97078, Wuerzburg, Germany.
Valérie Boivin-JahnsInstitute of Pharmacology and Toxicology, University of Würzburg, Versbacher Str. 9, D-97078, Wuerzburg, Germany.
University of Würzburg · DEComprehensive Cancer Center Mainfranken · DEHeinrich Heine University Düsseldorf · DEUniversity Medical Center Hamburg-Eppendorf · DE

Funding

Bundesministerium für Bildung und Forschung 01ES0901Bundesministerium für Bildung, Wissenschaft, Forschung und Technologie 0315363
6 · The paper itself

Abstract

aimsChronic heart failure (CHF) can be caused by autoantibodies stimulating the heart via binding to first and/or second extracellular loops of cardiac β METHODS AND

resultsNon-conserved amino acids within the β

conclusionsThe conformational auto-epitope targeted by cardio-pathogenic β

Indexed as

Cardiomyopathy, DilatedHeart FailureAnimalsAutoantibodiesEpitopesHumansMiceRabbitsRatsReceptors, Adrenergic, beta-1AutoantibodiesEpitopesReceptors, Adrenergic, beta-1Antibody/autoantibodyChronic heart failureConformational auto-epitopeCyclic peptides/cyclopeptidesCyclopeptide therapyβ1-adrenoceptor/β1-adrenergic receptor

Identifiers

PMID32436653
PMCPMC7373925
OpenAlexW3026419036

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.