Evidence map›Paper›PMID 32436355›Full record

ArticleAndrology2021

Low testosterone levels predict clinical adverse outcomes in SARS-CoV-2 pneumonia patients.

Giulia Rastrelli, Vincenza Di Stasi, Francesco Inglese, Massimiliano Beccaria, Martina Garuti, Domenica Di Costanzo, Fabio Spreafico, Graziana Francesca Greco, Giulia Cervi, Antonietta Pecoriello and 10 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Andrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 221 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
221citing papers in PubMed, 18 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

221 citing papers in PubMed, 18 syntheses or guidelines pooled it, 363 citations in OpenAlex.

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  6. Semen parameters and sex hormones as affected by SARS-CoV-2 infection: A systematic review.Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie · 2022
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161 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 1 country.

Giulia RastrelliDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", Andrology, Women's Endocrinology and Gender Incongruence Unit, University of Florence - Careggi Hospital, Florence, Italy.ORCID 0000-0002-6164-4278
Vincenza Di StasiDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", Andrology, Women's Endocrinology and Gender Incongruence Unit, University of Florence - Careggi Hospital, Florence, Italy.
Francesco IngleseIntensive Care Respiratory Unit, Mantova, Italy.
Massimiliano BeccariaIntensive Care Respiratory Unit, Mantova, Italy.
Martina GarutiIntensive Care Respiratory Unit, Mantova, Italy.
Domenica Di CostanzoIntensive Care Respiratory Unit, Mantova, Italy.
Fabio SpreaficoIntensive Care Respiratory Unit, Mantova, Italy.
Graziana Francesca GrecoIntensive Care Respiratory Unit, Mantova, Italy.
Giulia CerviIntensive Care Respiratory Unit, Mantova, Italy.
Antonietta PecorielloIntensive Care Respiratory Unit, Mantova, Italy.
Angela MaginiDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", Andrology, Women's Endocrinology and Gender Incongruence Unit, University of Florence - Careggi Hospital, Florence, Italy.
Tommaso TodiscoDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", Andrology, Women's Endocrinology and Gender Incongruence Unit, University of Florence - Careggi Hospital, Florence, Italy.
Sarah CiprianiDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", Andrology, Women's Endocrinology and Gender Incongruence Unit, University of Florence - Careggi Hospital, Florence, Italy.
Elisa MaseroliDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", Andrology, Women's Endocrinology and Gender Incongruence Unit, University of Florence - Careggi Hospital, Florence, Italy.
Giovanni CoronaEndocrinology Unit, Medical Department, Azienda Usl Bologna Maggiore-Bellaria Hospital, Bologna, Italy.ORCID 0000-0002-9894-2885
Andrea SaloniaDivision of Experimental Oncology, URI-Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy.ORCID 0000-0002-0595-7165
Andrea LenziDepartment of Experimental Medicine, La Sapienza University of Rome, Rome, Italy.ORCID 0000-0002-7711-0465
Mario MaggiDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", Endocrinology Unit, University of Florence, Careggi Hospital, Florence, Italy.ORCID 0000-0003-3267-4221
Giuseppe De DonnoIntensive Care Respiratory Unit, Mantova, Italy.
Linda VignozziDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", Andrology, Women's Endocrinology and Gender Incongruence Unit, University of Florence - Careggi Hospital, Florence, Italy.ORCID 0000-0003-0907-0630
European Society for Sexual Medicine · ITAzienda USL di Bologna · ITIRCCS Ospedale San Raffaele · ITIstituto Nazionale Biostrutture e Biosistemi · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe pandemic of new severe acute respiratory syndrome (SARS) due to coronavirus (CoV) 2 (SARS-CoV-2) has stressed the importance of effective diagnostic and prognostic biomarkers of clinical worsening and mortality. Epidemiological data showing a differential impact of SARS-CoV-2 infection on women and men have suggested a potential role for testosterone (T) in determining gender disparity in the SARS-CoV-2 clinical outcomes.

objectivesTo estimate the association between T level and SARS-CoV-2 clinical outcomes (defined as conditions requiring transfer to higher or lower intensity of care or death) in a cohort of patients admitted in the respiratory intensive care unit (RICU). MATERIALS AND

methodsA consecutive series of 31 male patients affected by SARS-CoV-2 pneumonia and recovered in the respiratory intensive care unit (RICU) of the "Carlo Poma" Hospital in Mantua were analyzed. Several biochemical risk factors (ie, blood count and leukocyte formula, C-reactive protein (CRP), procalcitonin (PCT), lactate dehydrogenase (LDH), ferritin, D-dimer, fibrinogen, interleukin 6 (IL-6)) as well as total testosterone (TT), calculated free T (cFT), sex hormone-binding globulin (SHBG), and luteinizing hormone (LH) were determined.

resultsLower TT and cFT were found in the transferred to ICU/deceased in RICU group vs groups of patients transferred to IM or maintained in the RICU in stable condition. Both TT and cFT showed a negative significant correlation with biochemical risk factors (ie, the neutrophil count, LDH, and PCT) but a positive association with the lymphocyte count. Likewise, TT was also negatively associated with CRP and ferritin levels. A steep increase in both ICU transfer and mortality risk was observed in men with TT < 5 nmol/L or cFT < 100 pmol/L. DISCUSSION AND

conclusionOur study demonstrates for the first time that lower baseline levels of TT and cFT levels predict poor prognosis and mortality in SARS-CoV-2-infected men admitted to RICU.

Indexed as

AgedAged, 80 and overBiomarkersCOVID-19Disease ProgressionDown-RegulationHospital MortalityHumansMaleMiddle AgedPredictive Value of TestsRisk AssessmentRisk FactorsTestosteroneTime FactorsTreatment OutcomeBiomarkersTestosteroneCOVID-19inflammatory markersmortalityprognosissex hormones

Identifiers

PMID32436355
PMCPMC7280645
OpenAlexW3028311423

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.