Evidence map›Paper›PMID 32436341›Full record

ArticleThe American journal on addictions2020

Alexithymia, Emotion-Regulation Strategies, and Traumatic Experiences in Prenatally Cocaine-Exposed Young Adults.

Kristen P Morie, Zu Wei Zhai, Marc N Potenza, Linda C Mayes

Open access · greenAbstract read
In one paragraph

Article in The American journal on addictions, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kristen P MorieDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.ORCID 0000-0001-5220-5604
Zu Wei ZhaiDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.ORCID 0000-0002-1874-6025
Marc N PotenzaDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.ORCID 0000-0002-6323-1354
Linda C MayesChild Study Center, Yale University School of Medicine, New Haven, Connecticut.
Yale University · USMiddlebury College · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Development of Reward Processing in prenatally exposed adolescents and young adultsK01DA042937 · NIDA · YALE UNIVERSITY · PI MORIE, KRISTEN PAULA · 2017 to 2021
$907k
NCATS NIH HHS UL1 TR001863NIDA NIH HHS K01 DA042937
6 · The paper itself

Abstract

BACKGROUND AND

objectivesExposure to early-life trauma may lead to maladaptive characteristics such as alexithymia, and thus to poorer emotional regulation. This relationship may also be influenced by exposure to substances prenatally. We hypothesized that increased alexithymia would be seen in those with prenatal cocaine exposure (PCE). Additionally, we hypothesized that early-life trauma would be associated with alexithymia, and that alexithymia would be associated with poor emotional reappraisal and emotional suppression.

methodsA moderated mediation model was developed to examine whether the hypothesized indirect relationship between trauma and emotional reappraisal through alexithymia was different in young adults with and without PCE (Total N = 57). Thirty-seven young adults with PCE and 20 with no such exposure, all of whom were members of a longitudinal cohort, were recruited for the study, and data concerning childhood trauma, alexithymia, and emotional regulation were collected. Intercorrelations were performed between the scores on each measure and moderated mediation models were constructed separately with emotional neglect or emotional abuse as the independent variable and emotional reappraisal or emotional suppression as the dependent variable.

resultsPCE status was associated with alexithymia, and alexithymia mediated the relationship between emotional neglect and emotional reappraisal in individuals with PCE but not those without. DISCUSSION AND

conclusionsThe data suggest that alexithymia is a mechanism underlying poor use of emotional reappraisal in PCE individuals. SCIENTIFIC SIGNIFICANCE: Individuals with early-life trauma and substance exposure may represent a vulnerable population, and alexithymia may play a key role in the development of emotional regulation skills in this population. (Am J Addict 2020;29:492-499).

Indexed as

Emotional RegulationAdultAffective SymptomsChildChild AbuseCocaineDopamine Uptake InhibitorsFemaleHumansLongitudinal StudiesMaleModels, PsychologicalPregnancyPrenatal Exposure Delayed EffectsPsychological TraumaRisk FactorsCocaineDopamine Uptake Inhibitors

Identifiers

PMID32436341
PMCPMC7657982
OpenAlexW3026172648

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.