Evidence map›Paper›PMID 32436304›Full record

ReviewOrthopaedic surgery2020

Role of MicroRNA, LncRNA, and Exosomes in the Progression of Osteoarthritis: A Review of Recent Literature.

Fang Xie, Yong-Li Liu, Xiu-Yuan Chen, Qian Li, Jia Zhong, Bin-Yu Dai, Xian-Fang Shao, Guan-Bao Wu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Orthopaedic surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 2 pooled it
5.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 2 syntheses or guidelines pooled it, 111 citations in OpenAlex.

  1. Pooled it
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  13. Branding a New Technological Outlook for Future Orthopaedics.Bioengineering (Basel, Switzerland) · 2025
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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Fang XieAffiliated Changde Hospital, Hunan University of Traditional Chinese Medicine, Changde, China.ORCID https://orcid.org/0000-0002-0039-8747
Yong-Li LiuAffiliated Changde Hospital, Hunan University of Traditional Chinese Medicine, Changde, China.
Xiu-Yuan ChenAffiliated Changde Hospital, Hunan University of Traditional Chinese Medicine, Changde, China.
Qian LiAffiliated Changde Hospital, Hunan University of Traditional Chinese Medicine, Changde, China.
Jia ZhongAffiliated Changde Hospital, Hunan University of Traditional Chinese Medicine, Changde, China.
Bin-Yu DaiAffiliated Changde Hospital, Hunan University of Traditional Chinese Medicine, Changde, China.
Xian-Fang ShaoAffiliated Changde Hospital, Hunan University of Traditional Chinese Medicine, Changde, China.
Guan-Bao WuDepartment of Orthopaedics, Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine, Changsha, China.
Hunan University of Traditional Chinese Medicine · CNHunan Academy of Traditional Chinese Medicine · CN

Funding

Changde Science and Technology Bureau 2012SK06Hunan Administration of Traditional Chinese Medicine 201902National Natural Science Foundation of China 81874476
6 · The paper itself

Abstract

Osteoarthritis (OA) is a common clinical degenerative disease characterized by the destruction of articular cartilage, which has an increasing impact on people's lives and social economy. The pathogenesis of OA is complex and unclear, and there is no effective way to block its progress. The study of the pathogenesis of OA is the prerequisite for the early diagnosis and effective treatment of OA. To define the pathogenesis of OA, this review considers the pathological mechanism of OA that involves microRNA, lncRNA, and exosomes. More and more evidence shows that microRNA, lncRNA, and exosomes are closely related to OA. MicroRNA inhibits the target gene by binding to the 3'- untranslated region of the targets. LncRNA usually competes with microRNA to regulate the expression level of downstream genes, while exosomes, as a carrier of intercellular information transfer, transmit the biological information of mother cells to target cells, and the effect of exosomes secreted by different cells on OA are different. In this review, we emphasized that different microRNA, lncRNA, and exosomes have different regulatory effects on chondrocyte proliferation and apoptosis, extracellular matrix degradation and inflammation. Besides, we classified and analyzed these molecules according to their effects on the progress of OA. Based on the analysis of the reported literature, this review reveals some pathogenesis of OA, and emphasizes that microRNA, lncRNA, and exosomes have great potential to assist early diagnosis and effective treatment of OA.

Indexed as

Disease ProgressionExosomesHumansMicroRNAsOsteoarthritisRNA, Long NoncodingMicroRNAsRNA, Long NoncodingExosomesLncRNAMicroRNAOsteoarthritis

Identifiers

PMID32436304
PMCPMC7307224
OpenAlexW3027686686

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.