Evidence map›Paper›PMID 32436224›Full record

ArticleBritish journal of pharmacology2020

Open-channel blocking action of volatile anaesthetics desflurane and sevoflurane on human voltage-gated K

Yutaka Fukushima, Akiko Kojima, Xinya Mi, Wei-Guang Ding, Hirotoshi Kitagawa, Hiroshi Matsuura

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Open channel block of Kv1.5 channels by HMQ1611.Frontiers in pharmacology · 2022
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yutaka FukushimaDepartment of Physiology, Shiga University of Medical Science, Otsu, Japan.
Akiko KojimaDepartment of Anesthesiology, Shiga University of Medical Science, Otsu, Japan.ORCID 0000-0002-9649-5495
Xinya MiDepartment of Physiology, Shiga University of Medical Science, Otsu, Japan.
Wei-Guang DingDepartment of Physiology, Shiga University of Medical Science, Otsu, Japan.
Hirotoshi KitagawaDepartment of Anesthesiology, Shiga University of Medical Science, Otsu, Japan.
Hiroshi MatsuuraDepartment of Physiology, Shiga University of Medical Science, Otsu, Japan.ORCID 0000-0003-1998-0996
Shiga University of Medical Science · JP

Funding

JSPS (The Japan Society for the Promotion of Science, Tokyo, Japan) KAKENHI 17K08536JSPS (The Japan Society for the Promotion of Science, Tokyo, Japan) KAKENHI 17K11050JSPS (The Japan Society for the Promotion of Science, Tokyo, Japan) KAKENHI 18K16445
6 · The paper itself

Abstract

background and purposeVolatile anaesthetics have been shown to differentially modulate mammalian Shaker-related voltage-gated potassium (K EXPERIMENTAL APPROACH: Thirteen single-point mutations were constructed within pore domain of hK KEY

resultsBoth desflurane and sevoflurane increased hK CONCLUSION AND IMPLICATIONS: Desflurane and sevoflurane exert an open-channel blocking action on hK

Indexed as

AnestheticsAnimalsComputer SimulationDesfluraneHumansMutagenesis, Site-DirectedSevofluraneAnestheticsDesfluraneSevoflurane

Identifiers

PMID32436224
PMCPMC7393063
OpenAlexW3027373194

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.