ArticleIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology2020
Changes in the severity of gastric mucosal inflammation associated with Helicobacter pylori in humans coinfected with intestinal helminths.
Article in Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- A Scoping Review of the Associations Between Ascariasis, Helicobacter pylori Infection and Gastric Pathologies.Parasite immunology · 2026Article
- The impact ofFrontiers in medicine · 2022Review
- Review
- Review
- How peptic ulcer disease could potentially lead to the lifelong, debilitating effects of chronic fatigue syndrome: an insight.Scientific reports · 2021Article
- Dual infective burden of Helicobacter pylori and intestinal parasites: Good or bad news for the host?Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2020Review
- Editorial commentary on the Indian Journal of Gastroenterology March-April 2020 issue.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2020Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThough a few studies in animal models suggest that intestinal helminths (IH) favorably affect evolution of gastritis associated with Helicobacter pylori (H. pylori) the studies supporting this concept in humans are only a few and are based on serological data.
methodsTo evaluate the possible influence of IH on the human gastric mucosa, three groups of Venezuelan adults with gastropathy (endoscopically diagnosed) were studied: H. pylori-/IH- (n = 17), H. pylori+/IH- (n = 18), and H. pylori+/IH+ (n = 11). Histological analysis (hematoxylin-eosin) and immunohistochemical staining (peroxidase) for cytokines interleukin-1beta (IL-1β), tumor necrosis factor alpha (TNF-α), gamma interferon (IFN-γ), and interleukin 4 (IL-4) were undertaken in gastric antral biopsies.
resultsExpression of the four cytokines was detected in all individuals in varying degrees, but proinflammatory cytokines were expressed in a higher degree in the H. pylori+/IH- group, mainly IL-1β (Th1-dominant immune response), associated with a higher degree of both histological inflammation and gastric cancer risk index (GCRI), as compared to the H. pylori-/IH- group. In contrast, an increased expression of IL-4 and a reduced expression of proinflammatory cytokines (Th2-dominant response), plus the tendency to a lower degree of mononuclear infiltration, mucosal atrophy in gastric corpus, and GCRI, were evidenced in the coinfected group.
conclusionsThe findings of the present study is perhaps the first histological evidence of a possible modulatory effect of IH on the gastric mucosal inflammatory response due to H. pylori infection in humans.
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