Evidence map›Paper›PMID 32436101›Full record

SynthesisJournal of neurology2020

Neurological manifestations associated with COVID-19: a review and a call for action.

Matilde Leonardi, Alessandro Padovani, Justin C McArthur

Registry-linked trialOpen access · bronzeAbstract readSystematic Review
In one paragraph

Synthesis in Journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04745611 (Neurological and Neuropsychological Sequelae of COVID-19 Infection), which is not on this map. Cited by 73 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 4 pooled it
12.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04745611 completednot on this map

Neurological and Neuropsychological Sequelae of COVID-19 Infection

Typeobservational_patient_registrySponsorMaastricht UniversityRan2020 to 2022Enrolled329ConditionsCOVID-19 InfectionArmsMRI, Neuropsychological assessment, Questionnaires Patient, Questionnaires Family
3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 4 syntheses or guidelines pooled it, 155 citations in OpenAlex.

  1. Pooled it
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  13. Changes in cerebral glucose metabolism among mild long COVID patients: an [18F]FDG PET/CT study.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2024
    Article
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13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Matilde LeonardiNeurology, Public Health, Disability Unit and Coma Research Centre, Italian WHO-Collaborating Centre Research Branch, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy. matilde.leonardi@istituto-besta.it.ORCID http://orcid.org/0000-0003-0552-8923
Alessandro PadovaniNeuroCovid Unit, Institute of Neurology, ASST Spedali Civili of Brescia, University of Brescia, Brescia, Italy.
Justin C McArthurNeurology, Pathology, Medicine, and Epidemiology, Sheikh Khalifa Stroke Institute, Johns Hopkins University School of Medicine, The Johns Hopkins Hospital, Baltimore, MD, USA.
Fondazione IRCCS Istituto Neurologico Carlo Besta · ITJohns Hopkins University · USUniversity of Brescia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While the epidemic of Coronavirus disease 2019 (COVID-19) continues to spread globally, more and more evidences are collected about the presence of neurological manifestations and symptoms associated with it. A systematic review has been performed of papers published until 5 April 2020. 29 papers related to neurological manifestations associated with COVID-19 were examined. The results show presence of central and peripheral nervous system manifestations related to coronavirus. Neurological manifestations, or NeuroCOVID, are part of the COVID-19 clinical picture, but questions remain regarding the frequency and severity of CNS symptoms, the mechanism of action underlying neurological symptoms, and the relationship of symptoms with the course and severity of COVID-19. Further clinical, epidemiological, and basic science research is urgently needed to understand and address neurological sequalae of COVID-19. Concomitant risk factors or determinants (e.g. demographic factors, comorbidities, or available biomarkers) that may predispose a person with COVID-19 to neurological manifestations also need to be identified. The review shows that although more and more papers are reporting neurological manifestations associated with COVID-19; however, many items remain unclear and this uncertainty calls for a global action that requires close coordination and open-data sharing between hospitals, academic institutions and the fast establishment of harmonised research priorities and research consortia to face the NeuroCOVID-19 complications.

Indexed as

BetacoronavirusCoronavirus InfectionsCOVID-19HumansNervous System DiseasesPandemicsPneumonia, ViralSARS-CoV-2Central nervous systemCOVID-19NeuroCOVIDNeurological symptomsPeripheral nervous systemResearch

Identifiers

PMID32436101
PMCPMC7238392
OpenAlexW3024635505

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.