ArticleEnvironmental science and pollution research international2020
Biochemical, hematological and immunological parameters and relationship with occupational exposure to pesticides and metals.
Article in Environmental science and pollution research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Shared Mechanism, Distinct Outcomes: Transcriptomic Analysis Reveals Differential Modulation of Metabolic and Detoxification Pathways by Neonicotinoid Insecticides.International journal of molecular sciences · 2026Article
- Effect of pesticide exposure on liver function tests and serum cholinesterase levels among floriculture industry workers in Bahirdar, Ethiopia: a comparative cross-sectional study.Scientific reports · 2026Article
- Integrated Network Analysis of Toxic Elements Co-exposure and Pathophysiological Changes Triggered by Oxidative Stress/Inflammation in Urban Sanitation Workers.Biological trace element research · 2026Article
- Flumetralin based plant growth regulator used in tobacco cultivation induces immune and cytotoxicity in vitro.Toxicology research · 2025Article
- Association Between Chromium and Lead Exposure and Liver Injury Biomarkers Among Adults in Addis Ababa, Ethiopia.Environmental health insights · 2025Article
- Cross-sectional and Longitudinal Associations Between Metal Mixtures and Serum C3, C4: Result from the Manganese‑exposed Workers Healthy Cohort.Biological trace element research · 2025Article
- Sub-Chronic Methomyl Exposure Induces Oxidative Stress and Inflammatory Responses in Zebrafish with Higher Female Susceptibility.Antioxidants (Basel, Switzerland) · 2024Article
- Mitochondrial impairment related to the immunotoxicity of the herbicides clomazone, glyphosate and sulfentrazone in THP-1 cells.Toxicology research · 2024Article
- Hematological indices as indicators of inflammation induced by exposure to pesticides.Environmental science and pollution research international · 2023Article
- Comparison of Biochemical, Haematological and Plasmatic Butyrylcholinesterase Parameters in Farmers and Non-Farmers, Morocco.Advanced biomedical research · 2023Article
- The association between blood, urine, respiratory, neurobehavioral parameters and occupational exposure to organophosphorus pesticides: a cross-sectional study among formulators.African health sciences · 2022Article
- Health Effects of Pesticide Exposure in Latin American and the Caribbean Populations: A Scoping Review.Environmental health perspectives · 2022Article
- Impact of Pesticides on Human Health in the Last Six Years in Brazil.International journal of environmental research and public health · 2022Review
- Association between Haematological Parameters and Exposure to a Mixture of Organophosphate and Neonicotinoid Insecticides among Male Farmworkers in Northern Thailand.International journal of environmental research and public health · 2021Article
- Adverse Health Effects in Women Farmers Indirectly Exposed to Pesticides.International journal of environmental research and public health · 2021Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
Abstract
This study aimed to evaluate biomarkers of exposure to cholinesterase inhibitors insecticides (AChE and BuChE activities) and metals (As, Cd, Cr, Mn, Ni, and Pb blood levels) and their associations with biochemical, hematological, and immunological parameters in farmers from Southern Brazil. One hundred and sixteen individuals were divided into two groups: 62 farmers (exposed group) and 54 subjects non-occupationally exposed (NOE) to agrochemicals. Erythrocyte (AChE) and serum (BuChE) cholinesterases activities were significantly reduced as well as blood Cd and Pb levels were increased in farmers when compared to NOE group (p < 0.05). Farmers presented increased glucose and urea levels compared to NOE group, which were inversely associated with AChE and positively correlated with Cd (p < 0.05), respectively. In addition, Cd was inversely associated with the hematological cells counts, which were significantly reduced in farmers (p < 0.05). C3 complement was higher in farmers and was positively associated with blood Pb (p < 0.05). Surface protein expression analysis revealed a downregulation of LFA-1 and ICAM-1 in farmers. Inverse associations were found between LFA-1 and blood As, Cr, and Ni levels (p < 0.05). Taken together, our results pointed to a relationship between agrochemicals and metals exposure and biochemical, hematological, and immunological disorders that can lead to several chronic conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.