Evidence map›Paper›PMID 32436083›Full record

ArticlePharmaceutical research2020

Correlations Between Skin Barrier Integrity and Delivery of Hydrophilic Molecules in the Presence of Penetration Enhancers.

XueKe Lin, ZhenHua Wang, HuiLong Ou, Samir Mitragotri, Ming Chen

Abstract read
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In one paragraph

Article in Pharmaceutical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. New Horizons in Dermal and Transdermal Drug Delivery Systems.Pharmaceuticals (Basel, Switzerland) · 2023
    Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

XueKe LinState-Province Joint Engineering Laboratory of Marine Bioproducts and Technology, Department of Marine Biological Science & Technology, College of Ocean & Earth Science, Xiamen University, Xiamen, 361102, China.
ZhenHua WangDepartment of Cardiology, Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, China.
HuiLong OuState-Province Joint Engineering Laboratory of Marine Bioproducts and Technology, Department of Marine Biological Science & Technology, College of Ocean & Earth Science, Xiamen University, Xiamen, 361102, China.
Samir MitragotriSchool of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, 02138, USA.
Ming ChenState-Province Joint Engineering Laboratory of Marine Bioproducts and Technology, Department of Marine Biological Science & Technology, College of Ocean & Earth Science, Xiamen University, Xiamen, 361102, China. ming.chen@xmu.edu.cn.
Xiamen University · CNHarvard University · USSecond Affiliated Hospital of Fujian Medical University · CN

Funding

Fujian Provincial Department of Health 2015-ZQN-ZD-24Fujian Provincial Department of Ocean and Fisheries FJHJF-L-2019-03Fujian Provincial Department of Science and Technology 2017Y4015
6 · The paper itself

Abstract

purposeWe investigated the potential correlations between skin barrier integrity and hydrophilic drugs distribution in skin in the presence of different types of penetration enhancers (PEs) and their combinations.

methodsWe measured skin conductivity to evaluate skin barrier integrity before and after the topical application of different chemical PEs, physical PE, peptide PE and their combinations in vitro. We also investigated their effect on the skin distribution profiles of two hydrophilic model drugs, Fluorescein sodium (376 Da) and Fluorescein isothiocyanate-dextrans 10 (10 KDa).

resultsThe physical PE significantly increased the skin conductivity compared to all other PEs, while the peptide PE had no effect on it. The drug deposition in different skin layers was not only dependent on PE applied but also its own molecular weight. We further found two excellent correlations: one (R

conclusionsThe total skin absorption or the deposition in dermis and receptor of small hydrophilic drug in the presence of chemical and physical PEs and their combinations show a good correlation with skin barrier integrity. However, such correlations hold true neither for large hydrophilic drug nor for peptide PE. All good relationships found in this work will allow screening suitable PEs or combinations by measuring the skin conductivity induced by corresponding PEs. Graphical Abstract The total skin absorption of small hydrophilic drug shows a good correlation with skin barrier integrity in the presence of chemical and physical penetration enhancers and their combinations. However, such a correlation hold true neither for large hydrophilic drug nor for peptide penetration enhancer.

Indexed as

Administration, CutaneousAnimalsBiomedical EnhancementDextransDrug CarriersDrug CompoundingDrug LiberationExcipientsFluoresceinFluorescein-5-isothiocyanateGuinea PigsHumansHydrophobic and Hydrophilic InteractionsIn Vitro TechniquesMolecular ConformationMolecular StructureDextransDrug CarriersExcipientsFluoresceinFluorescein-5-isothiocyanatefluorescein isothiocyanate dextranPeptidesPharmaceutical Preparationspenetration enhancersporous pathway theoryskin drug distribution

Identifiers

PMID32436083
OpenAlexW3026879870

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.