ArticleHistochemistry and cell biology2020
Effect of light on the calretinin and calbindin expression in skin club cells of adult zebrafish.
Article in Histochemistry and cell biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Alimentary Tract Anatomy and Morphology in Early Adult Mediterranean KillifishAnimals : an open access journal from MDPI · 2026Article
- The Skin Photophores ofAnimals : an open access journal from MDPI · 2025Article
- Piezo 1 and Piezo 2 in the Chemosensory Organs of Zebrafish (International journal of molecular sciences · 2024Article
- Neurotrophins and Trk Neurotrophin Receptors in the Retina of Adult Killifish (International journal of molecular sciences · 2024Article
- Localization of Calretinin, Parvalbumin, and S100 Protein inLife (Basel, Switzerland) · 2023Article
- Immunohistochemistry of the Gut-Associated Lymphoid Tissue (GALT) in African Bonytongue (International journal of molecular sciences · 2023Article
- Potential Neuroprotective Role of Calretinin-N18 and Calbindin-D28k in the Retina of Adult Zebrafish Exposed to Different Wavelength Lights.International journal of molecular sciences · 2023Article
- Article
- Localization of vasoactive intestinal peptide and toll-like receptor 2 immunoreactive cells in endostyle of urochordate Styela plicata (Lesueur, 1823).Microscopy research and technique · 2022Article
- Learning by Doing: The Use of Distance, Corners and Length in Rewarded Geometric Tasks by Zebrafish (Animals : an open access journal from MDPI · 2021Article
- Epidermal Club Cells in Fishes: A Case for Ecoimmunological Analysis.International journal of molecular sciences · 2021Review
- Introduction: in vivo cell biology in zebrafish.Histochemistry and cell biology · 2020Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the last decade, zebrafish has been used as a model for the study of several human skin diseases. The epidermis of Danio rerio is composed of keratinocytes and two types of secretory cells: mucous cells and club cells. Club cells have multiple biological functions and among them may be important in the protection against ultraviolet damage through the proliferative response or through the increased production of protective substances. Calcium-binding proteins such as calbindin D28K and calretinin are used as markers of nervous and enteric nervous systems, but they are present in numerous other cells. These proteins are involved in a wide variety of cell activities, such as cytoskeletal organization, cell motility and differentiation, cell cycle regulation and neuroprotective function. In this study we demonstrated, for the first time, the presence of calretinin and calbindin D28K in skin club cells of Danio rerio exposed to different wavelengths by immunohistochemistry analysis. Exposure to white-blue light and blue light causes the expression and colocalization of calbindin-D28K and calretinin. These proteins were moderately expressed and no colocalization was observed in the club cells of the control fish. In zebrafish exposed to continuous darkness for 10 days, in the club cells the two antibodies did not detect any proteins specifically. These results demonstrate that calbindin and calretinin could be involved in the pathophysiology of skin injury due to exposure to short-wavelength visible light spectrums.
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