Evidence map›Paper›PMID 32435879›Full record

ArticlePediatric nephrology (Berlin, Germany)2020

SARS-CoV-2 infection in Spanish children with chronic kidney pathologies.

M Melgosa, A Madrid, O Alvárez, J Lumbreras, F Nieto, E Parada, V Perez-Beltrán, Spanish Pediatric Nephrology Association

Open access · greenAbstract read
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 8 pooled it
1.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 8 syntheses or guidelines pooled it, 79 citations in OpenAlex.

  1. Pooled it
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  3. Asymptomatic SARS-CoV-2 infection: A systematic review and meta-analysis.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Pooled it
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  9. Review
  10. Article
  11. Vaccines and nephrotic syndrome: efficacy and safety.Pediatric nephrology (Berlin, Germany) · 2023
    Review
  12. Article
  13. Article
  14. SARS-CoV-2 infection in children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2022
    Article
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  17. Observational
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 1 country.

M MelgosaPediatric Nephrology Department, La Paz University Hospital, Madrid, Spain. marta.melgosa@salud.madrid.org.ORCID 0000-0001-6236-414X
A MadridPediatric Nephrology Department, Sant Joan de Deu University Hospital, Barcelona, Spain.
O AlvárezPediatric Nephrology Department, Gregorio Marañón University Hospital, Madrid, Spain.
J LumbrerasPediatric Nephrology Department, Son Espases University Hospital, Palma de Mallorca, Spain.
F NietoPediatric Nephology Department, Malaga University Hospital, Málaga, Spain.
E ParadaPediatric Nephrology Department, Joan XXIII University Hospital, Tarragona, Spain.
V Perez-BeltránPediatric Nephrology Department, Vall d'Hebron University Hospital, Barcelona, Spain.
Spanish Pediatric Nephrology Association
Hospital General Universitario Gregorio Marañón · ESHospital Sant Joan de Déu Barcelona · ESHospital Universitari Joan XXIII de Tarragona · ESHospital Universitario La Paz · ESHospital Universitario Son Espases · ESUniversidad de Málaga · ESVall d'Hebron Hospital Universitari · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is little information about Coronavirus Disease 2019 (COVID-19) in children with underlying chronic renal pathologies. CASES REPORT: From March until April 15, 2020, 16 children with chronic renal pathologies were diagnosed with COVID-19 in Spain. Of these, 6 had end-stage kidney disease (ESKD) (3 transplant recipients and 3 on chronic hemodialysis). The severity of symptoms was mild in all the patients, with little radiological involvement. Three patients were asymptomatic. Fever and upper respiratory symptoms were the most frequent findings. Basal glomerular filtration worsened in 3 patients; however, recovery was rapidly achieved with rehydration and drug dose adjustment. In 2 patients diagnosed with steroid-dependent nephrotic syndrome, COVID-19 provoked a disease relapse. None required oxygen therapy, and 7 could be managed as outpatients.

conclusionsCOVID-19 disease appears to have a similar clinical course in children with underlying chronic renal pathologies, even in immunosuppressed cases, as in healthy children of the same age; however, special attention must be paid to fluid management and drug dose adjustment.

Indexed as

BetacoronavirusAdolescentAntiviral AgentsChildChild, PreschoolCoronavirus InfectionsCOVID-19FemaleHumansHydroxychloroquineImmunocompetenceInfantMalePandemicsPneumonia, ViralRenal Insufficiency, ChronicAntiviral AgentsHydroxychloroquineChildrenCKDCOVID-19ImmunosuppressionNephrotic syndrome

Identifiers

PMID32435879
PMCPMC7237873
OpenAlexW3025686722

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.