Evidence map›Paper›PMID 32435817›Full record

ReviewDer Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete2020

[European Guidelines (S1) on the use of high-dose intravenous immunoglobulin in dermatology].

Eva Hadaschik, Rüdiger Eming, Lars E French, Giampiero Girolomoni, Michael Hertl, Stephen Jolles, Sarolta Karpati, Kerstin Steinbrink, Georg Stingl, Beatrix Volc-Platzer and 2 more

Open access · hybridAbstract readReview
PubMed Publisher
In one paragraph

Review in Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Article
  4. [Targeted therapies in Pyoderma gangrenosum: deciphering pathophysiology and improving disease management].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 5 countries.

Eva HadaschikHautklinik, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 440, 69120, Heidelberg, Deutschland.
Rüdiger EmingKlinik für Dermatologie und Allergologie, Philipps-Universität Marburg, Marburg, Deutschland.
Lars E FrenchDermatologische Klinik, Universität Zürich, Zürich, Schweiz.
Giampiero GirolomoniAbteilung für Dermatologie, Universität Verona, Verona, Italien.
Michael HertlKlinik für Dermatologie und Allergologie, Philipps-Universität Marburg, Marburg, Deutschland.
Stephen JollesImmundefizienz-Zentrum für Wales, Universitätskrankenhaus Wales, Cardiff, Großbritannien.
Sarolta KarpatiAbteilung für Dermatologie, Semmelweis-Universität Budapest, Budapest, Ungarn.
Kerstin SteinbrinkUniversitäts-Hautklinik, Johannes-Gutenberg-Universität Mainz, Mainz, Deutschland.
Georg StinglUniversitätsklinik für Dermatologie, Medizinische Universität Wien, Wien, Österreich.
Beatrix Volc-PlatzerUniversitätsklinik für Dermatologie, Medizinische Universität Wien, Wien, Österreich.
Detlef ZillikensKlinik für Dermatologie, Allergologie und Venerologie, Universität zu Lübeck, Lübeck, Deutschland.
Alexander EnkHautklinik, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 440, 69120, Heidelberg, Deutschland. alexander.enk@med.uni-heidelberg.de.
Heidelberg University · DEMedical University of Vienna · ATPhilipps University of Marburg · DEJohannes Gutenberg University Mainz · DESemmelweis University · HUUniversity of Lübeck · DEUniversity of Verona · ITUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesTreatment of severe dermatological autoimmune diseases and toxic epidermal necrolysis (TEN) with high-dose intravenous immunoglobulin (IVIg) is a well-established procedure in dermatology. As treatment with IVIg is usually considered for rare clinical entities or severe cases, the use of immunoglobulin is not generally based on data from randomized controlled trials usually required for evidence-based medicine. Since the indications for the use of IVIg are rare, it is unlikely that such studies will be available in the foreseeable future. Because first-line use is limited by the high costs of IVIg, the first clinical guidelines on the use of IVIg in dermatological conditions were established in 2008 and renewed in 2011.

methodsThe European guidelines presented here were prepared by a panel of experts nominated by the European Dermatology Forum (EDF) and European Academy of Dermatology and Venereology (EADV). The guidelines were developed to update the indications for treatment currently considered effective and to summarize the evidence for the use of IVIg in dermatological autoimmune diseases and TEN. RESULTS AND

conclusionThe current guidelines represent consensual expert opinions and definitions on the use of IVIg reflecting current published evidence and are intended to serve as a decision-making tool for the use of IVIg in dermatological diseases.

Indexed as

Practice Guidelines as TopicAutoimmune DiseasesDermatologyDose-Response Relationship, DrugEuropeHumansImmunoglobulins, IntravenousSkin DiseasesStevens-Johnson SyndromeImmunoglobulins, IntravenousAutoimmune diseasesDecision treeDosingExpert consensusTherapy

Identifiers

PMID32435817
OpenAlexW3027599360

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.