Evidence map›Paper›PMID 32435669›Full record

ArticleNeurobiology of stress2020

Composite contributions of cerebrospinal fluid GABAergic neurosteroids, neuropeptide Y and interleukin-6 to PTSD symptom severity in men with PTSD.

Byung Kil Kim, Jennifer R Fonda, Richard L Hauger, Graziano Pinna, George M Anderson, Ivan T Valovski, Ann M Rasmusson

Open access · goldAbstract read
In one paragraph

Article in Neurobiology of stress, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
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  10. PTSD, Immune System, and Inflammation.Advances in experimental medicine and biology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 1 country.

Byung Kil KimVA Boston Healthcare System, 150 South Huntington Ave., Boston, MA, 02130, USA.
Jennifer R FondaVA Boston Healthcare System, 150 South Huntington Ave., Boston, MA, 02130, USA.
Richard L HaugerCenter of Excellence for Stress and Mental Health, VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA, 92161, USA.
Graziano PinnaThe Psychiatric Institute, College of Medicine, University of Illinois at Chicago, 1601 W Taylor St. MC912 Chicago, IL, 60612, USA.
George M AndersonChild Study Center and Department of Laboratory Medicine, Yale University School of Medicine S. Frontage Rd. New Haven, CT, 06519, USA.
Ivan T ValovskiVA Boston Healthcare System, 150 South Huntington Ave., Boston, MA, 02130, USA.
Ann M RasmussonVA Boston Healthcare System, 150 South Huntington Ave., Boston, MA, 02130, USA.
Boston University · USHarvard University · USUniversity of California San Diego · USUniversity of Illinois Chicago · USVA Boston Healthcare System · USYale University · US

Funding

GABAergic Neurotransmission in PTSDR21MH081113 · NIMH · YALE UNIVERSITY · PI RASMUSSON, ANN M. · 2007 to 2008
$378k
NIMH NIH HHS R21 MH081113
6 · The paper itself

Abstract

Given that multiple neurobiological systems, as well as components within these systems are impacted by stress, and may interact in additive, compensatory and synergistic ways to promote or mitigate PTSD risk, severity, and recovery, we thought that it would be important to consider the

Indexed as

3α-HSD, 3α-hydroxysteroid dehydrogenaseAllo + PA, sum of allopregnanolone and pregnanoloneEIA, enzyme immunoassayGC-MS, gas chromatography-mass spectrometryHPLC, high pressure liquid chromatographyLP, lumbar puncturePE, prolonged exposure therapyPFC, prefrontal cortexRIA, radioimmunoassayTC, trauma-exposed control

Identifiers

PMID32435669
PMCPMC7231970
OpenAlexW3017305035

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.