Evidence map›Paper›PMID 32435666›Full record

ArticleNeurobiology of stress2020

Amygdala functional connectivity in the acute aftermath of trauma prospectively predicts severity of posttraumatic stress symptoms.

Emily L Belleau, Lauren E Ehret, Jessica L Hanson, Karen J Brasel, Christine L Larson, Terri A deRoon-Cassini

Open access · goldAbstract read
In one paragraph

Article in Neurobiology of stress, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Mechanistic signatures of comorbid PTSD with cognitive impairment implicate cortisol-induced neural toxicity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  6. Sequential decreases in basolateral amygdala response to threat predict failure to recover from PTSD.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Traumatic stress alters neural reactivity to visual stimulation.NPP - digital psychiatry and neuroscience · 2025
    Article
  15. Article
  16. Review
  17. Article
  18. Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Emily L BelleauMcLean Hospital, Center for Depression, Anxiety and Stress Research, Belmont, MA, USA.
Lauren E EhretRogers Behavioral Health, Minneapolis, MN, USA.
Jessica L HansonUniversity of Wisconsin-Milwaukee, Department of Psychology, Milwaukee, WI, USA.
Karen J BraselOregon Health and Science University, Department of Surgery, Portland, OR, USA.
Christine L LarsonUniversity of Wisconsin-Milwaukee, Department of Psychology, Milwaukee, WI, USA.
Terri A deRoon-CassiniMedical College of Wisconsin, Department of Surgery, Division of Trauma & Acute Care Surgery, Milwaukee, WI, USA.
University of Wisconsin–Milwaukee · USHarvard University · USMedical College of Wisconsin · USOregon Health & Science University · USRogers Behavioral Health · US

Funding

Acute Neurocognitive-affective Predictors of Chronic Post-trauma OutcomesR01MH106574 · NIMH · UNIVERSITY OF WISCONSIN MILWAUKEE · PI LARSON, CHRISTINE L · 2015 to 2019
$3.1M
Imaging genetics of extinction of conditioned fear responses in anxietyK01MH086809 · NIMH · UNIVERSITY OF WISCONSIN MILWAUKEE · PI LARSON, CHRISTINE L · 2010 to 2014
$854k
NIMH NIH HHS K01 MH086809NIMH NIH HHS R01 MH106574
6 · The paper itself

Abstract

Understanding neural mechanisms that confer risk for posttraumatic stress disorder (PTSD) is critical for earlier intervention, yet longitudinal work has been sparse. The amygdala is part of a core network consistently implicated in PTSD symptomology. Most neural models of PTSD have focused on the amygdala's interactions with the dorsal anterior cingulate cortex, ventromedial prefrontal cortex, and hippocampus. However, an increasing number of studies have linked PTSD symptoms to aberrations in amygdala functional connections with other brain regions involved in emotional information processing, self-referential processing, somatosensory processing, visual processing, and motor control. In the current study, trauma-exposed individuals (

Indexed as

AmygdalaFunctional connectivityLongitudinal studyPosttraumatic stress disorder (PTSD)Trauma

Identifiers

PMID32435666
PMCPMC7231977
OpenAlexW3014806463

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.