Evidence map›Paper›PMID 32435665›Full record

ArticleNeurobiology of stress2020

Allopregnanolone: From molecular pathophysiology to therapeutics. A historical perspective.

Steven M Paul, Graziano Pinna, Alessandro Guidotti

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Neurobiology of stress, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06759558 (Allopregnanolone), which is not on this map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06759558 phase2recruitingnot on this mapstarted 2026, after this paper: background citation

Allopregnanolone (Zuranolone) in Post-stroke Depression

TypeinterventionalSponsorDuke UniversityRan2026 to 2026Enrolled6ConditionsPost Stroke DepressionArmsZuranolone
3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 97 citations in OpenAlex.

  1. Efficacy and safety of zuranolone co-initiated with an antidepressant in adults with major depressive disorder: results from the phase 3 CORAL study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Trial
  2. Review
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  4. Gendering the Menstrual Cycle in Behavioral Neuroendocrinology.American journal of human biology : the official journal of the Human Biology Council · 2026
    Review
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Steven M PaulDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Graziano PinnaThe Psychiatric Institute, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Alessandro GuidottiThe Psychiatric Institute, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
University of Illinois Chicago · USWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Allopregnanolone is synthesized in the central nervous system either

Indexed as

AllopregnanoloneBrexanoloneGABAA receptorsMood disordersNeurosteroidsPostpartum depressionZulresso

Identifiers

PMID32435665
PMCPMC7231972
OpenAlexW3010885451

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.