Evidence map›Paper›PMID 32435464›Full record

ReviewBone & joint research2020

Patients with metabolic syndrome have a greater rate of complications after arthroplasty: A systematic review and meta-analysis.

Cui Guofeng, Yue Chen, Wei Rong, Liu Ruiyu, Wang Kunzheng

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bone & joint research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Impact of Metabolic Syndrome on Patient-Reported and Clinical Outcomes in Patients Undergoing Primary Total Joint Arthroplasty.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026
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  19. A Predictive Model of Metabolic Syndrome by Medical Examination: Evidence from an 8-Year Chinese Cohort.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Cui GuofengDepartment of Orthopedics, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, China; Department of Orthopedics, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Yue ChenDepartment of Orthopedic Surgery, Luoyang Orthopedic Hospital of Henan Province, Luoyang, China.
Wei RongDepartment of Orthopedics, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, China.
Liu RuiyuDepartment of Orthopedics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Wang KunzhengDepartment of Orthopedics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Second Affiliated Hospital of Xi'an Jiaotong University · CNLuoyang Central Hospital Affiliated to Zhengzhou University · CNLuoyang Orthopedic-Traumatological Hospital of Henan Province · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsPatients with metabolic syndrome (MetS) are known to be at increased risk of postoperative complications, but it is unclear whether MetS is also associated with complications after total hip arthroplasty (THA) or total knee arthroplasty (TKA). Here, we perform a systematic review and meta-analysis linking MetS to postoperative complications in THA and TKA.

methodsThe PubMed, OVID, and ScienceDirect databases were comprehensively searched and studies were selected and analyzed according to the guidelines of the Meta-analysis of Observational Studies in Epidemiology (MOOSE). We assessed the methodological quality of each study using the Newcastle-Ottawa Scale (NOS), and we evaluated the quality of evidence using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE). Data were extracted and meta-analyzed or qualitatively synthesized for several outcomes.

resultsTen cohort studies involving 1,352,685 patients were included. Qualitative analysis suggested that MetS was associated with a higher incidence of cardiovascular events, and meta-analysis showed that MetS increased the risk of all-cause complications (risk ratio (RR) 1.55, 95% confidence interval (CI) 1.28 to 1.89), surgical site infection (SSI; RR 2.99, 95% CI 1.30 to 6.90), urinary tract infection (UTI; RR 2.58, 95% CI 1.03 to 6.43), and 30-day readmission (RR 1.45, 95% CI 1.33 to 1.59). There was insufficient evidence for assessing an association between MetS and venous thromboembolism events, pulmonary or gastrointestinal complications, or mortality.

conclusionPatients with MetS undergoing THA and TKA are at increased risk of all-cause complications, cardiovascular complications, SSI, UTI, and 30-day readmission. Surgeons should be aware of the increased risk of these complications in MetS, and presurgical protocols for these complications should give special consideration to MetS patients.

Indexed as

ComplicationsMetabolic syndromeTotal hip arthroplastyTotal knee arthroplasty

Identifiers

PMID32435464
PMCPMC7229294
OpenAlexW3010598345

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.