ArticleDental research journal
Expression of epidermal growth factor receptor in oral and esophageal squamous-cell carcinoma.
Article in Dental research journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Prognostic and Clinicopathological Significance of Epidermal Growth Factor Receptor (EGFR) Expression in Oral Squamous Cell Carcinoma: Systematic Review and Meta-Analysis.International journal of molecular sciences · 2023Pooled it
- Waterpipe smoke condensate activates the oncogenes and promotes epithelial-mesenchymal transition to cause oral cancer.Odontology · 2026Article
- Molecular Targets of Plant-Derived Bioactive Compounds in Oral Squamous Cell Carcinoma.Cancers · 2024Review
- Near-Infrared Photoimmunotherapy Using a Protein Mimetic for EGFR-Positive Salivary Gland Cancer.International journal of molecular sciences · 2024Article
- The impact of altering the concentration of coffee constituents on their anticancer effect on oral squamous cell carcinoma cell line -Contemporary oncology (Poznan, Poland) · 2024Article
- Proton Compared to X-Irradiation Induces Different Protein Profiles in Oral Cancer Cells and Their Derived Extracellular Vesicles.International journal of molecular sciences · 2023Article
- Nuclear Epidermal Growth Factor Receptor Overexpression as a Survival Predictor in Oral Squamous Cell Carcinoma.International journal of molecular sciences · 2023Article
- Nanoliposomal Coencapsulation ofIET nanobiotechnology · 2023Article
- Unveiling the anticancer effect of cytisine against oral cancer: Insights from bioinformatics andJournal of oral and maxillofacial pathology : JOMFPArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSquamous-cell carcinoma (SCC) represents the most common type of malignancies in the oral cavity (O) and esophagus (E). Epidermal growth factor receptor (EGFR) plays a key role in numerous processes that affects tumor growth, progression, differentiation, invasion, metastasis, and inhibition of apoptosis. In this study, we wanted to investigate the EGFR expression in OSCC and ESCC cases. As well, another purpose was to observe if there exists any relation between its expression and clinicopathologic factors. To the best of our knowledge, this is the first study which compares the EGFR protein expression between OSCC and ESCC. MATERIALS AND
methodsThis cross-sectional study was performed on 46 paraffin blocks (23 OSCC and 23 ESCC). The expression of EGFR was evaluated with immunohistochemical technique. Data analyses were done using SPSS software by Fisher's exact test. Significance was assigned at
resultsOut of 46 patients, 25 cases (54.3%) were male and 21 (45.7%) were female. Seventy-eight percent of OSCCs and 73.9% of ESCCs showed high expression of EGFR. No statistically significant difference was observed between the two groups (
conclusionNo significant correlation was found between the expression of EGFR protein in OSCCs and ESCCs. High expression of EGFR was observed in ESCCs with Stages II, III.
Indexed as
Identifiers
32435429PMC7224265W3011955290What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.