Evidence map›Paper›PMID 32435425›Full record

ArticleACS medicinal chemistry letters2020

Factor H-Inspired Design of Peptide Biomarkers of the Complement C3d Protein.

Reed E S Harrison, Nehemiah T Zewde, Yogesh B Narkhede, Rohaine V Hsu, Dimitrios Morikis, Valentine I Vullev, Giulia Palermo

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Reed E S HarrisonDepartment of Bioengineering and Department of Chemistry, University of California Riverside, 900 University Avenue, Riverside California 92507, United States.
Nehemiah T ZewdeDepartment of Bioengineering and Department of Chemistry, University of California Riverside, 900 University Avenue, Riverside California 92507, United States.
Yogesh B NarkhedeDepartment of Bioengineering and Department of Chemistry, University of California Riverside, 900 University Avenue, Riverside California 92507, United States.
Rohaine V HsuDepartment of Bioengineering and Department of Chemistry, University of California Riverside, 900 University Avenue, Riverside California 92507, United States.
Dimitrios MorikisDepartment of Bioengineering and Department of Chemistry, University of California Riverside, 900 University Avenue, Riverside California 92507, United States.
Valentine I VullevDepartment of Bioengineering and Department of Chemistry, University of California Riverside, 900 University Avenue, Riverside California 92507, United States.
Giulia PalermoDepartment of Bioengineering and Department of Chemistry, University of California Riverside, 900 University Avenue, Riverside California 92507, United States.
University of California, Riverside · US

Funding

Discovery of Biomarkers for Age-Related Macular DegenerationR01EY027440 · NEI · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI VULLEV, VALENTINE · 2017 to 2020
$1.5M
NEI NIH HHS R01 EY027440
6 · The paper itself

Abstract

C3d is a hallmark protein of the complement system, whose presence is critical to measure the progression of several immune diseases. Here, we propose to directly target C3d through small peptides mimicking the binding of its natural ligand, the complement regulator Factor H (FH). Through iterative computational analysis and binding affinity experiments, we establish a rationale for the structure-based design of FH-inspired peptides, leading to low-micromolar affinity for C3d and stable binding over microsecond-length simulations. Our FH-inspired peptides call now for further optimization toward high-affinity binding and suggest that small peptides are promising as novel C3d biomarkers and therapeutic tools.

Identifiers

PMID32435425
PMCPMC7236534
OpenAlexW3007485624

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.