Evidence map›Paper›PMID 32435278›Full record

ArticleGut pathogens2020

Type IV secretion of

Nicole Tegtmeyer, Tabita Denisia Ghete, Verena Schmitt, Torsten Remmerbach, Maria Celeste C Cortes, Edgardo M Bondoc, Hans-Ludwig Graf, Bernhard B Singer, Christian Hirsch, Steffen Backert

Open access · goldAbstract read
In one paragraph

Article in Gut pathogens, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Determinants ofBMJ open · 2026
    Article
  3. Frontiers in cell and developmental biology · 2025
    Article
  4. Article
  5. International journal of molecular sciences · 2022
    Review
  6. Review
  7. Engagement of CEACAM1 byMicroorganisms · 2021
    Article
  8. International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Nicole Tegtmeyer1Department of Biology, Division of Microbiology, Friedrich Alexander University Erlangen, Staudtstrasse 5, 91058 Erlangen, Germany.ORCID 0000-0002-6300-1831
Tabita Denisia Ghete1Department of Biology, Division of Microbiology, Friedrich Alexander University Erlangen, Staudtstrasse 5, 91058 Erlangen, Germany.
Verena Schmitt2Medical Faculty, Institute of Anatomy, University of Duisburg-Essen, Hufelandstrasse 55, 45147 Essen, Germany.ORCID https://orcid.org/0000-0002-6951-6406
Torsten Remmerbach3Division of Clinical and Experimental Oral Medicine, Department of OMF-Surgery, Leipzig University Hospital, University of Leipzig, Leipzig, Germany.
Maria Celeste C Cortes4Center for Basic Science Research (CBSR), Research and Biotechnology (R&B), St. Luke's Medical Center, Quezon City, Philippines.
Edgardo M Bondoc5Institute for Digestive and Liver Diseases, St. Luke's Medical Center, Quezon City, Philippines.
Hans-Ludwig Graf6Department of Oral, Maxillary, Facial and Reconstructive Plastic Surgery, University Hospital of Leipzig, Leipzig, Germany.
Bernhard B Singer2Medical Faculty, Institute of Anatomy, University of Duisburg-Essen, Hufelandstrasse 55, 45147 Essen, Germany.ORCID https://orcid.org/0000-0002-2213-6000
Christian Hirsch7Department of Paediatric Dentistry, University School of Dental Medicine, University of Leipzig, Leipzig, Germany.
Steffen Backert1Department of Biology, Division of Microbiology, Friedrich Alexander University Erlangen, Staudtstrasse 5, 91058 Erlangen, Germany.
Friedrich-Alexander-Universität Erlangen-Nürnberg · DESt. Luke's Medical Center · PHUniversity Hospital Leipzig · DEUniversity of Duisburg-Essen · DELeipzig University of Applied Sciences · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background

resultsAll three oral cell lines were resistant to elongation upon infection, despite similar bacterial binding capabilities. Moreover, T4SS-dependent CagA injection was absent. Resistance to CagA delivery was shown to be due to absence of CEACAM expression in these cell lines, while these surface molecules have recently been recognized as

conclusionsThese results show that lack of CEACAM receptors on the surface of the oral epithelial cells was responsible for resistance to

Indexed as

AGSBHYCagACAL-27CEACAMHNSignalingT4SSType IV secretionTyrosine kinases

Identifiers

PMID32435278
PMCPMC7222478
OpenAlexW3026142491

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.