Evidence map›Paper›PMID 32435207›Full record

ArticleFrontiers in physiology2020

Relationships Between Chemoreflex Responses, Sleep Quality, and Hematocrit in Andean Men and Women.

Erica C Heinrich, Jeremy E Orr, Dillon Gilbertson, Cecilia Anza-Ramirez, Pamela N DeYoung, Matea A Djokic, Noemi Corante, Gustavo Vizcardo-Galindo, Jose L Macarlupu, Eduardo Gaio and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Altitude hypoxia and hypoxemia: pathogenesis and management.Signal transduction and targeted therapy · 2026
    Review
  5. Article
  6. AdaptiveiScience · 2025
    Article
  7. Article
  8. Article
  9. Altitude illnesses.Nature reviews. Disease primers · 2024
    Review
  10. FunctionalScience advances · 2024
    Article
  11. Review
  12. Article
  13. Article
  14. Isovolemic hemodilution in chronic mountain sickness acutely worsens nocturnal oxygenation and sleep apnea severity.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022
    Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 3 countries.

Erica C HeinrichDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of California, San Diego, San Diego, CA, United States.
Jeremy E OrrDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of California, San Diego, San Diego, CA, United States.
Dillon GilbertsonDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of California, San Diego, San Diego, CA, United States.
Cecilia Anza-RamirezLaboratorio de Fisiología Comparada/Fisiología del Transporte de Oxígen, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru.
Pamela N DeYoungDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of California, San Diego, San Diego, CA, United States.
Matea A DjokicDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of California, San Diego, San Diego, CA, United States.
Noemi CoranteLaboratorio de Fisiología Comparada/Fisiología del Transporte de Oxígen, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru.
Gustavo Vizcardo-GalindoLaboratorio de Fisiología Comparada/Fisiología del Transporte de Oxígen, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru.
Jose L MacarlupuLaboratorio de Fisiología Comparada/Fisiología del Transporte de Oxígen, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru.
Eduardo GaioFaculty of Medicine, University of Brasília, Brasília, Brazil.
Frank L PowellDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of California, San Diego, San Diego, CA, United States.
Atul MalhotraDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of California, San Diego, San Diego, CA, United States.
Francisco C VillafuerteLaboratorio de Fisiología Comparada/Fisiología del Transporte de Oxígen, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru.
Tatum S SimonsonDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of California, San Diego, San Diego, CA, United States.
University of California, San Diego · USUniversidad Peruana Cayetano Heredia · PEUniversidade de Brasília · BR

Funding

Neural Plasticity During Acclimatization to HypoxiaR01HL081823 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI POWELL, FRANK L. · 2005 to 2019
$4.5M
Single Motor Unit Genioglossus Recordings to Understand Sleep Apnea PathogenesisR01HL085188 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2008 to 2018
$3.5M
Imaging Blood Flow, Ventilation, and Density InteractionsR01HL119201 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HOPKINS, SUSAN R · 2016 to 2019
$2.5M
Respiratory and genomic contributions to adaptive/maladaptive hypoxia responsesR01HL145470 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SIMONSON, TATUM S · 2019 to 2023
$2.4M
Training in the Next Generation in Respiratory ScienceT32HL134632 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL, POWELL, FRANK L. · 2017 to 2021
$2.1M
Assessment of Upper Airway Mechanics Using Newer Electromyographic TechniquesK24HL132105 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2016 to 2020
$611k
MR Imaging of Upper Airway Dynamics in Obstructive Sleep ApneaR21HL121794 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DARQUENNE, CHANTAL · 2014 to 2015
$423k
The Contribution of Ventilatory Instability to Sleep Disordered Breathing in Pulmonary HypertensionF32HL131306 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ORR, JEREMY ELLIOT · 2016 to 2017
$139k
Genetic determinants of variation in the hypoxic ventilatory response in low- and high-altitude populationsF32HL131218 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HEINRICH, ERICA · 2016 to 2018
$127k
Integrating physiology and genomics to reveal functional adaptation in high-altitK99HL118215 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SIMONSON, TATUM S · 2014 to 2014
$85k
NHLBI NIH HHS F32 HL131218NHLBI NIH HHS F32 HL131306NHLBI NIH HHS K24 HL132105NHLBI NIH HHS K99 HL118215NHLBI NIH HHS R01 HL081823NHLBI NIH HHS R01 HL085188NHLBI NIH HHS R01 HL119201NHLBI NIH HHS R01 HL145470NHLBI NIH HHS R21 HL121794NHLBI NIH HHS T32 HL134632Wellcome Trust
6 · The paper itself

Abstract

Andean highlanders are challenged by chronic hypoxia and many exhibit elevated hematocrit (Hct) and blunted ventilation compared to other high-altitude populations. While many Andeans develop Chronic Mountain Sickness (CMS) and excessive erythrocytosis, Hct varies markedly within Andean men and women and may be driven by individual differences in ventilatory control and/or sleep events which exacerbate hypoxemia. To test this hypothesis, we quantified relationships between resting ventilation and ventilatory chemoreflexes, sleep desaturation, breathing disturbance, and Hct in Andean men and women. Ventilatory measures were made in 109 individuals (

Indexed as

control of breathingexcessive erythrocytosishigh altitudehypoxiasleep

Identifiers

PMID32435207
PMCPMC7219107
OpenAlexW3021645612

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.