Evidence map›Paper›PMID 32435178›Full record

ArticleFrontiers in neuroscience2020

Myriocin Effect on Tvrm4 Retina, an Autosomal Dominant Pattern of Retinitis Pigmentosa.

Ilaria Piano, Vanessa D'Antongiovanni, Elena Novelli, Martina Biagioni, Michele Dei Cas, Rita Clara Paroni, Riccardo Ghidoni, Enrica Strettoi, Claudia Gargini

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 69 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Light as a Mediator of Acute and Chronic Retina Degeneration.Advances in experimental medicine and biology · 2025
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Rod Photoreceptor Neuroprotection in Dark-Reared Pde6brd10 Mice.Investigative ophthalmology & visual science · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Ilaria PianoDepartment of Pharmacy, University of Pisa, Pisa, Italy.
Vanessa D'AntongiovanniDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Elena NovelliCNR Institute of Neuroscience, Pisa, Italy.
Martina BiagioniCNR Institute of Neuroscience, Pisa, Italy.
Michele Dei CasDepartment of Health Sciences, University of Milan, Milan, Italy.
Rita Clara ParoniDepartment of Health Sciences, University of Milan, Milan, Italy.
Riccardo GhidoniDepartment of Health Sciences, University of Milan, Milan, Italy.
Enrica StrettoiCNR Institute of Neuroscience, Pisa, Italy.
Claudia GarginiDepartment of Pharmacy, University of Pisa, Pisa, Italy.
Neuroscience Institute · ITUniversity of Milan · ITUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tvrm4 mice, a model of autosomal dominant retinitis pigmentosa (RP), carry a mutation of Rhodopsin gene that can be activated by brief exposure to very intense light. Here, we test the possibility of an anatomical, metabolic, and functional recovery by delivering to degenerating Tvrm4 animals, Myriocin, an inhibitor of ceramide

Indexed as

mutation-independent approachMyriocinoxidative stressphotoreceptor rescueretinitis pigmentosa

Identifiers

PMID32435178
PMCPMC7218082
OpenAlexW3021253105

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.