Evidence map›Paper›PMID 32435057›Full record

Trial reportBritish journal of cancer2020

Fatigue, quality of life and physical fitness following an exercise intervention in multiple myeloma survivors (MASCOT): an exploratory randomised Phase 2 trial utilising a modified Zelen design.

Dimitrios A Koutoukidis, Joanne Land, Allan Hackshaw, Malgorzata Heinrich, Orla McCourt, Rebecca J Beeken, Stephanie Philpott, Dunnya DeSilva, Ali Rismani, Neil Rabin and 7 more

Open access · hybridAbstract readClinical Trial, Phase IIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in British journal of cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 7 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 7 syntheses or guidelines pooled it, 70 citations in OpenAlex.

  1. Pooled it
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  11. Article
  12. Exercise for myeloma patients with bone disease: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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  13. Review
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  20. Exercise interventions in patients with multiple myeloma: a scoping review.BMC sports science, medicine & rehabilitation · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 1 country.

Dimitrios A Koutoukidis *Department of Behavioural Science and Health, University College London, London, UK.
Joanne Land *Department of Behavioural Science and Health, University College London, London, UK.
Allan HackshawCancer Research UK & UCL Cancer Trials Centre, University College London, London, UK.
Malgorzata HeinrichDepartment of Behavioural Science and Health, University College London, London, UK.
Orla McCourtDepartment of Behavioural Science and Health, University College London, London, UK.
Rebecca J BeekenDepartment of Behavioural Science and Health, University College London, London, UK.ORCID http://orcid.org/0000-0001-8287-9351
Stephanie PhilpottDepartment of Behavioural Science and Health, University College London, London, UK.
Dunnya DeSilvaCancer Institute, University College London, London, UK.
Ali RismaniDepartment of Haematology, University College London Hospitals NHS Foundation Trust, London, UK.
Neil RabinDepartment of Haematology, University College London Hospitals NHS Foundation Trust, London, UK.
Rakesh PopatDepartment of Haematology, University College London Hospitals NHS Foundation Trust, London, UK.
Charalampia KyriakouDepartment of Haematology, University College London Hospitals NHS Foundation Trust, London, UK.
Xenofon PapanikolaouDepartment of Haematology, Lister Hospital, Stevenage, UK.
Atul MehtaDepartment of Haematology, University College London Hospitals NHS Foundation Trust, London, UK.
Bruce PatonInstitute of Sport, Exercise and Health, London, UK.
Abigail FisherDepartment of Behavioural Science and Health, University College London, London, UK.
Kwee L YongCancer Institute, University College London, London, UK. kwee.yong@ucl.ac.uk.
University College London · GBUniversity College London Hospitals NHS Foundation Trust · GBCancer Research UK · GBEnglish Institute of Sport · GBLister Hospital · GBUniversity of Leeds · GBUniversity of Oxford · GB

Funding

Cancer Research UK 14133Cancer Research UK (CRUK) C1418/A14133
6 · The paper itself

Abstract

backgroundExercise may improve fatigue in multiple myeloma survivors, but trial evidence is limited, and exercise may be perceived as risky in this older patient group with osteolytic bone destruction.

methodsIn this Phase 2 Zelen trial, multiple myeloma survivors who had completed treatment at least 6 weeks ago, or were on maintenance only, were enrolled in a cohort study and randomly assigned to usual care or a 6-month exercise programme of tailored aerobic and resistance training. Outcome assessors and usual care participants were masked. The primary outcome was the FACIT-F fatigue score with higher scores denoting less fatigue.

resultsDuring 2014-2016, 131 participants were randomised 3:1 to intervention (n = 89) or usual care (n = 42) to allow for patients declining allocation to the exercise arm. There was no difference between groups in fatigue at 3 months (between-group mean difference: 1.6 [95% CI: -1.1-4.3]) or 6 months (0.3 [95% CI: -2.6-3.1]). Muscle strength improved at 3 months (8.4 kg [95% CI: 0.5-16.3]) and 6 months (10.8 kg [95% CI: 1.2-20.5]). Using per-protocol analysis, cardiovascular fitness improved at 3 months (+1.2 ml/kg/min [95% CI: 0.3-3.7]). In participants with clinical fatigue (n = 17), there was a trend towards less fatigue with exercise over 6 months (6.3 [95% CI: -0.6-13.3]). There were no serious adverse events.

conclusionsExercise appeared safe and improved muscle strength and cardiovascular fitness, but benefits in fatigue appeared limited to participants with clinical fatigue at baseline. Future studies should focus on patients with clinical fatigue. CLINICAL

trial registrationThe study was registered with ISRCTN (38480455) and is completed.

Indexed as

AdultAgedAged, 80 and overCancer SurvivorsCohort StudiesExercise TherapyFatigueFemaleHumansMaleMiddle AgedMultiple MyelomaPhysical FitnessQuality of LifeSurvivors

Identifiers

PMID32435057
PMCPMC7374110
OpenAlexW3016105669

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.