Evidence map›Paper›PMID 32434931›Full record

ArticleThe Journal of biological chemistry2020

Unveiling the activation dynamics of a fold-switch bacterial glycosyltransferase by

Jobst Liebau, Montse Tersa, Beatriz Trastoy, Joan Patrick, Ane Rodrigo-Unzueta, Francisco Corzana, Tobias Sparrman, Marcelo E Guerin, Lena Mäler

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Fold-Switching Proteins.Annual review of biophysics · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Metamorphic proteins and how to find them.Current opinion in structural biology · 2024
    Review
  9. Fluid protein fold space and its implications.BioEssays : news and reviews in molecular, cellular and developmental biology · 2023
    Article
  10. Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2023
    Article
  11. Article
  12. Article
  13. Assessing the applicability ofJournal of biomolecular NMR · 2023
    Article
  14. Distinguishing features of fold-switching proteins.Protein science : a publication of the Protein Society · 2023
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. The Phosphatidyl-Journal of bacteriology · 2021
    Article
  20. A suite ofJournal of biomolecular NMR · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jobst LiebauDepartment of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.ORCID 0000-0003-4057-6699
Montse TersaStructural Biology Unit, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain.ORCID 0000-0002-2370-7776
Beatriz TrastoyStructural Biology Unit, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain.
Joan PatrickDepartment of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
Ane Rodrigo-UnzuetaDepartamento de Bioquímica and Instituto Biofisika, Consejo Superior de Investigaciones Científicas-Universidad del País Vasco/Euskal Herriko Unibertsitatea (CSIC, UPV/EHU), Bizkaia, Spain.
Francisco CorzanaDepartamento de Química, Centro de Investigación en Síntesis Química, Universidad de La Rioja, Logroño, Spain.ORCID 0000-0001-5597-8127
Tobias SparrmanDepartment of Chemistry, Umeå University, Umeå, Sweden.
Marcelo E GuerinStructural Biology Unit, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Derio, Spain mrcguerin@cicbiogune.es lena.maler@dbb.su.se.
Lena MälerDepartment of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden mrcguerin@cicbiogune.es lena.maler@dbb.su.se.ORCID 0000-0002-9464-4311

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fold-switch pathways remodel the secondary structure topology of proteins in response to the cellular environment. It is a major challenge to understand the dynamics of these folding processes. Here, we conducted an in-depth analysis of the α-helix-to-β-strand and β-strand-to-α-helix transitions and domain motions displayed by the essential mannosyltransferase PimA from mycobacteria. Using

Indexed as

Molecular Dynamics SimulationProtein FoldingBacterial ProteinsMannosyltransferasesMycobacterium smegmatisNuclear Magnetic Resonance, BiomolecularBacterial ProteinsMannosyltransferasesphosphatidyl-myo-inositol mannosyltransferase PimA, Mycobacterium smegmatis19F NMRcarbohydrate active enzymesconformational dynamicsenzyme catalysisglycosyltransferasesprotein fold-switching, protein dynamicsprotein functionprotein structurerelaxation dispersion

Identifiers

PMID32434931
PMCPMC7380196

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.