Evidence map›Paper›PMID 32434928›Full record

ArticleThe Journal of biological chemistry2020

The transcriptional corepressor CBFA2T3 inhibits all-

Nickolas Steinauer, Chun Guo, Jinsong Zhang

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

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  13. The predictive prognostic values ofAnnals of translational medicine · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Nickolas SteinauerDepartment of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri, USA.
Chun GuoDepartment of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri, USA.
Jinsong ZhangDepartment of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, Missouri, USA. Electronic address: jinsong.zhang@health.slu.edu.
Saint Louis University · US

Funding

Pharmacological Sciences Training GrantT32GM008306 · NIGMS · SAINT LOUIS UNIVERSITY · PI EGAN, TERRANCE M, WALKER, JOHN K. · 1990 to 2020
$3.6M
Aberrant hematopoiesis: E proteins and AML1-ETO in leukemogenesisR01HL093195 · NHLBI · UNIVERSITY OF CINCINNATI · PI ZHANG, JINSONG · 2009 to 2013
$1.9M
Human HDAC3: mechanism of activation and proteasomal degradationR21CA178513 · NCI · SAINT LOUIS UNIVERSITY · PI ZHANG, JINSONG · 2014 to 2015
$362k
NCI NIH HHS R21 CA178513NHLBI NIH HHS R01 HL093195NIGMS NIH HHS T32 GM008306
6 · The paper itself

Abstract

CBFA2/RUNX1 partner transcriptional co-repressor 3 (CBFA2T3, also known as MTG16 or ETO2) is a myeloid translocation gene family protein that functions as a master transcriptional corepressor in hematopoiesis. Recently, it has been shown that CBFA2T3 maintains leukemia stem cell gene expression and promotes relapse in acute myeloid leukemia (AML). However, a role for CBFA2T3 in myeloid differentiation of AML has not been reported. Here, we show that CBFA2T3 represses retinoic acid receptor (RAR) target gene expression and inhibits all-

Indexed as

Cell DifferentiationCo-Repressor ProteinsGene ExpressionGene Expression Regulation, LeukemicHumansLeukemia, Myeloid, AcuteMyeloid CellsReceptors, Retinoic AcidRepressor ProteinsRetinoic Acid Receptor alphaTretinoinTumor Suppressor ProteinsCBFA2T3 protein, humanCo-Repressor ProteinsReceptors, Retinoic AcidRepressor ProteinsRetinoic Acid Receptor alphaTretinoinTumor Suppressor Proteinsacute myeloid leukemia (AML)all-trans-retinoic acid (ATRA)cancer biologyCBFA2/RUNX1 partner transcriptional co-repressor 3 (CBFA2T3)cell differentiationchromatin accessibilitychromatin immunoprecipitation (ChIP)chromatin regulationepigeneticsgene transcriptionhistone acetylationhistone acetyltransferasenuclear receptortranscriptional corepressortranscription corepressor

Identifiers

PMID32434928
PMCPMC7335779
OpenAlexW3028150170

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.