ArticleThe Journal of biological chemistry2020
A bacterial biosynthetic pathway for methylated furan fatty acids.
Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Lipid droplet proteome plasticity in plant evolution, growth and development, and response to stress.Journal of experimental botany · 2026Review
- Arabidopsis root lipid droplets are hubs for membrane homeostasis under heat stress, and triterpenoid synthesis and storage.The New phytologist · 2026Article
- The emerging significance of furan fatty acids in food, nutrition, and potential therapeutic use.Food chemistry · 2025Review
- Effect of SAM-Dependent Methyltransferases fromJournal of microbiology and biotechnology · 2025Article
- Evolutionarily related host and microbial pathways regulate fat desaturation in C. elegans.Nature communications · 2024Article
- Lipid droplets inFrontiers in plant science · 2024Article
- Enhanced Bioremediation Potential ofFrontiers in microbiology · 2022Article
- Chlamydomonas as a model for reactive oxygen species signaling and thiol redox regulation in the green lineage.Plant physiology · 2021Review
- Solving a furan fatty acid biosynthesis puzzle.The Journal of biological chemistry · 2020Article
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Authors and funding
10 authors.
Funding
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Abstract
Fatty acids play many important roles in cells and also in industrial processes. Furan fatty acids (FuFAs) are present in the lipids of some plant, fish, and microbial species and appear to function as second messengers in pathways that protect cells from membrane-damaging agents. We report here the results of chemical, genetic, and synthetic biology experiments to decipher the biosynthesis of the monomethylated FuFA, methyl 9-(3-methyl-5-pentylfuran-2-yl) nonanoate (9M5-FuFA), and its dimethyl counterpart, methyl 9-(3,4-dimethyl-5-pentylfuran-2-yl) nonanoate (9D5-FuFA), in two α-proteobacteria. Each of the steps in FuFA biosynthesis occurs on pre-existing phospholipid fatty acid chains, and we identified pathway intermediates and the gene products that catalyze 9M5-FuFA and 9D5-FuFA synthesis in
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