Evidence map›Paper›PMID 32434881›Full record

ArticleImmunoHorizons2020

Silke E Lindner, Colt A Egelston, Stephanie M Huard, Peter P Lee, Leo D Wang

Open access · goldAbstract read
In one paragraph

Article in ImmunoHorizons, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Silke E LindnerDepartment of Immuno-Oncology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010; and.ORCID 0000-0003-4956-3931
Colt A EgelstonDepartment of Immuno-Oncology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010; and.ORCID 0000-0001-8440-1271
Stephanie M HuardDepartment of Immuno-Oncology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010; and.ORCID 0000-0002-2333-1852
Peter P LeeDepartment of Immuno-Oncology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010; and.ORCID 0000-0002-2660-4377
Leo D WangDepartment of Immuno-Oncology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010; and leo.wang@coh.org.ORCID 0000-0002-2945-9005
City Of Hope National Medical Center · US

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI STANLEY R. HAMILTON · 1985 to 2026
$86.3M
Targeting the ARHGAP25 pathway in acute myelogenous leukemia stem cellsK08CA201591 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI WANG, LEO D. · 2017 to 2021
$848k
NCI NIH HHS K08 CA201591NCI NIH HHS P30 CA033572
6 · The paper itself

Abstract

Rho family GTPases are critical for normal B cell development and function, and their activity is regulated by a large and complex network of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). However, the role of GAPs in B cell development is poorly understood. In this study, we show that the novel Rac-GAP ARHGAP25 is important for B cell development in mice in a CXCR4-dependent manner. We show that

Indexed as

AnimalsB-LymphocytesChemotaxisGerminal CenterGTPase-Activating ProteinsGuanine Nucleotide Exchange FactorsMiceMice, Inbred C57BLMice, KnockoutReceptors, CXCR4ARHGAP25 protein, mouseCXCR4 protein, mouseGTPase-Activating ProteinsGuanine Nucleotide Exchange FactorsReceptors, CXCR4

Identifiers

PMID32434881
PMCPMC7301639
OpenAlexW3027370582

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.